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• W2580344553 startingPage "1383" @default.
• W2580344553 abstract "Significance Autism spectrum disorders (ASDs) comprise a heterogeneous set of neurodevelopmental disorders. Although hundreds of genes have now been identified to be associated with ASD, genetic factors cannot fully explain ASD’s incidence. The early environment is now known to be pivotal in ASD’s etiology too. In the face of this complexity, one aspect of ASD has stood out constantly as a causative biological factor: the sex difference. Approximately 80% of the children diagnosed are boys. This current set of experiments tests, in an animal model, the “three-hit theory of autism,” which states that interactions among ( i ) being male, ( ii ) suffering early (especially, prenatal/immunological) stress, and ( iii ) having certain genetic mutations will predispose to an ASD diagnosis." @default.
• W2580344553 created "2017-02-03" @default.
• W2580344553 creator A5041146783 @default.
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• W2580344553 date "2017-01-23" @default.
• W2580344553 modified "2023-10-15" @default.
• W2580344553 title "Sex-specific gene–environment interactions underlying ASD-like behaviors" @default.
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• W2580344553 doi "https://doi.org/10.1073/pnas.1619312114" @default.
• W2580344553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5307430" @default.
• W2580344553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28115688" @default.
• W2580344553 hasPublicationYear "2017" @default.
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