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- W2580367665 abstract "The objective of this thesis is to provide more insight in the association of bacterial genetics with clinical characteristics of patients with bacterial meningitis. In a genetic association study using a cohort of 258 meningococcal meningitis patients, we show that specific meningococcal clonal complexes, meningococcal factor H binding protein (fHbp) types and meningococcal two-partner secretion system distribution are associated with clinical outcome. In a study contributing to vaccine research, we describe the genetic distribution of the 3 meningococcal antigens that are included in the serogroup B meningococcal vaccine in meningococcal isolates collected in the Netherlands over a period of 50 years. We report the availability of the N. meningitidis serogroup B H44/76 genome sequence, a strain widely used in molecular genetics studies. Also we analyze the genome of a clinical meningococcal meningitis isolate without lipopolysaccharide (LPS) and show that a mutation located in lpxH, which encodes an enzyme in the lipid A biosynthesis pathway, explains its LPS-deficiency. Finally we identified pneumococcal arginine biosynthesis genes to be associated with clinical outcome in patients with pneumococcal meningitis, using a clinical phenotype-based approach combined with bacterial whole-genome sequencing. This thesis, in which more than half of our analyses are based on newly sequenced bacterial whole genome sequences, serves as a proof of principle that bacterial whole-genome sequencing can give answers to research questions that previously remained unanswered. This thesis has contributed to a better understanding of the role of bacterial genetics in the clinical course and outcome of bacterial meningitis." @default.
- W2580367665 created "2017-02-03" @default.
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- W2580367665 date "2016-01-01" @default.
- W2580367665 modified "2023-09-27" @default.
- W2580367665 title "Bacterial genetics in meningitis: Associating meningococcal and pneumococcal genes with clinical outcome" @default.
- W2580367665 hasPublicationYear "2016" @default.
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