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- W2580456492 abstract "Significance Immunoglobulins exist in several forms, or isotypes, that carry out distinct effector functions. During an antibody response, B cells can switch their immunoglobulin isotype through the process of class-switch recombination (CSR). CSR to IgD is a rare event compared with CSR to other isotypes, and its regulation is poorly understood. Here we report that mice lacking the DNA damage-response protein 53BP1 display a hyper-IgD syndrome despite deficiencies of other immunoglobulin classes. By studying these mice, we discovered that CSR to IgD in 53BP1 mutant mice and in wild-type mice depends on an intact microbiome and Toll-like receptor signaling, and is anatomically confined to B cells of mucosa-associated lymphoid tissues." @default.
- W2580456492 created "2017-02-03" @default.
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- W2580456492 date "2017-01-30" @default.
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- W2580456492 title "IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice" @default.
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- W2580456492 doi "https://doi.org/10.1073/pnas.1621258114" @default.
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