Matches in SemOpenAlex for { <https://semopenalex.org/work/W2580490691> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2580490691 abstract "Cells express a large array of membrane receptors on their surface that function as a communication channel between the extra- and intracellular environment of the cell. Ligands for these receptors span a wide range of biomolecules, from proteins to carbohydrates to small molecules. Some receptors are continuously recycling between the membrane and the inside of a cell, whereas others are in a steady-state at the membrane and need ligand binding for their activation and subsequent internalization. Synthetic molecules that bind to these membrane receptors can be used to either modulate their function, or to target a reporter group (i.e. a fluorescent dye) and/or a bio-active compound (drug, protein) to cells that express this receptor, ensuring delivery to a specific cell-type. The research described in this Thesis combines synthetic and biochemical methodologies to create ligands that interact selectively with membrane receptors of the GPCR and lectin-binding families. Attachment of synthetic probes, proteins or cytostatic molecules to these ligands by a variety of chemical and enzymatic methods ensured their uptake exclusively into cells that expressed the receptor of interest. Visualization of this process was enabled by the incorporation of a fluorescent dye into the final constructs." @default.
- W2580490691 created "2017-02-03" @default.
- W2580490691 creator A5082156658 @default.
- W2580490691 date "2014-01-23" @default.
- W2580490691 modified "2023-09-27" @default.
- W2580490691 title "A chemical biology approach for targeting of ligand-drug conjugates" @default.
- W2580490691 hasPublicationYear "2014" @default.
- W2580490691 type Work @default.
- W2580490691 sameAs 2580490691 @default.
- W2580490691 citedByCount "0" @default.
- W2580490691 crossrefType "journal-article" @default.
- W2580490691 hasAuthorship W2580490691A5082156658 @default.
- W2580490691 hasConcept C116569031 @default.
- W2580490691 hasConcept C12554922 @default.
- W2580490691 hasConcept C126511603 @default.
- W2580490691 hasConcept C135285700 @default.
- W2580490691 hasConcept C139770010 @default.
- W2580490691 hasConcept C144647389 @default.
- W2580490691 hasConcept C1491633281 @default.
- W2580490691 hasConcept C161624437 @default.
- W2580490691 hasConcept C170493617 @default.
- W2580490691 hasConcept C171852809 @default.
- W2580490691 hasConcept C178790620 @default.
- W2580490691 hasConcept C185592680 @default.
- W2580490691 hasConcept C197462201 @default.
- W2580490691 hasConcept C2778106830 @default.
- W2580490691 hasConcept C2779820397 @default.
- W2580490691 hasConcept C41625074 @default.
- W2580490691 hasConcept C49853544 @default.
- W2580490691 hasConcept C55493867 @default.
- W2580490691 hasConcept C79879829 @default.
- W2580490691 hasConcept C86803240 @default.
- W2580490691 hasConcept C95444343 @default.
- W2580490691 hasConceptScore W2580490691C116569031 @default.
- W2580490691 hasConceptScore W2580490691C12554922 @default.
- W2580490691 hasConceptScore W2580490691C126511603 @default.
- W2580490691 hasConceptScore W2580490691C135285700 @default.
- W2580490691 hasConceptScore W2580490691C139770010 @default.
- W2580490691 hasConceptScore W2580490691C144647389 @default.
- W2580490691 hasConceptScore W2580490691C1491633281 @default.
- W2580490691 hasConceptScore W2580490691C161624437 @default.
- W2580490691 hasConceptScore W2580490691C170493617 @default.
- W2580490691 hasConceptScore W2580490691C171852809 @default.
- W2580490691 hasConceptScore W2580490691C178790620 @default.
- W2580490691 hasConceptScore W2580490691C185592680 @default.
- W2580490691 hasConceptScore W2580490691C197462201 @default.
- W2580490691 hasConceptScore W2580490691C2778106830 @default.
- W2580490691 hasConceptScore W2580490691C2779820397 @default.
- W2580490691 hasConceptScore W2580490691C41625074 @default.
- W2580490691 hasConceptScore W2580490691C49853544 @default.
- W2580490691 hasConceptScore W2580490691C55493867 @default.
- W2580490691 hasConceptScore W2580490691C79879829 @default.
- W2580490691 hasConceptScore W2580490691C86803240 @default.
- W2580490691 hasConceptScore W2580490691C95444343 @default.
- W2580490691 hasLocation W25804906911 @default.
- W2580490691 hasOpenAccess W2580490691 @default.
- W2580490691 hasPrimaryLocation W25804906911 @default.
- W2580490691 hasRelatedWork W1979968480 @default.
- W2580490691 hasRelatedWork W1981009270 @default.
- W2580490691 hasRelatedWork W1991456836 @default.
- W2580490691 hasRelatedWork W1995555037 @default.
- W2580490691 hasRelatedWork W2008447696 @default.
- W2580490691 hasRelatedWork W2039196177 @default.
- W2580490691 hasRelatedWork W2108977657 @default.
- W2580490691 hasRelatedWork W2128530763 @default.
- W2580490691 hasRelatedWork W2258905208 @default.
- W2580490691 hasRelatedWork W2501380727 @default.
- W2580490691 hasRelatedWork W2586145470 @default.
- W2580490691 hasRelatedWork W2610010539 @default.
- W2580490691 hasRelatedWork W2940859099 @default.
- W2580490691 hasRelatedWork W2984969958 @default.
- W2580490691 hasRelatedWork W3009826822 @default.
- W2580490691 hasRelatedWork W3044162805 @default.
- W2580490691 hasRelatedWork W3045165633 @default.
- W2580490691 hasRelatedWork W70239342 @default.
- W2580490691 hasRelatedWork W2604536968 @default.
- W2580490691 hasRelatedWork W2803847166 @default.
- W2580490691 isParatext "false" @default.
- W2580490691 isRetracted "false" @default.
- W2580490691 magId "2580490691" @default.
- W2580490691 workType "article" @default.