Matches in SemOpenAlex for { <https://semopenalex.org/work/W2580497425> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2580497425 abstract "Biomarkers have the potential to improve diagnosis and prognosis, facilitate-targeted treatment, and reduce health care costs. Thus, there is great hope that biomarkers will be integrated in all clinical decisions in the near future. A decade ago, the biomarker field was launched with great enthusiasm because MS revealed that blood contains a rich library of candidate biomarkers. However, biomarker research has not yet delivered on its promise due to several limitations: (i) improper sample handling and tracking as well as limited sample availability in the pediatric population, (ii) omission of appropriate controls in original study designs, (iii) lability and low abundance of interesting biomarkers in blood, and (iv) the inability to mechanistically tie biomarker presence to disease biology. These limitations as well as successful strategies to overcome them are discussed in this review. Several advances in biomarker discovery and validation have been made in hematopoietic stem cell transplantation, the current most effective tumor immunotherapy, and these could serve as examples for other conditions. This review provides fresh optimism that biomarkers clinically relevant in pediatrics are closer to being realized based on: (i) a uniform protocol for low-volume blood collection and preservation, (ii) inclusion of well-controlled independent cohorts, (iii) novel technologies and instrumentation with low analytical sensitivity, and (iv) integrated animal models for exploring potential biomarkers and targeted therapies." @default.
- W2580497425 created "2017-02-03" @default.
- W2580497425 creator A5006134549 @default.
- W2580497425 creator A5010413445 @default.
- W2580497425 creator A5017952176 @default.
- W2580497425 creator A5022327161 @default.
- W2580497425 creator A5040158605 @default.
- W2580497425 creator A5052684200 @default.
- W2580497425 creator A5069809093 @default.
- W2580497425 creator A5069919013 @default.
- W2580497425 creator A5076234152 @default.
- W2580497425 date "2014-12-01" @default.
- W2580497425 modified "2023-09-30" @default.
- W2580497425 title "Opportunities and challenges of proteomics in pediatric patients: circulating biomarkers after hematopoietic stem cell transplantation as a successful example" @default.
- W2580497425 hasPublicationYear "2014" @default.
- W2580497425 type Work @default.
- W2580497425 sameAs 2580497425 @default.
- W2580497425 citedByCount "0" @default.
- W2580497425 crossrefType "journal-article" @default.
- W2580497425 hasAuthorship W2580497425A5006134549 @default.
- W2580497425 hasAuthorship W2580497425A5010413445 @default.
- W2580497425 hasAuthorship W2580497425A5017952176 @default.
- W2580497425 hasAuthorship W2580497425A5022327161 @default.
- W2580497425 hasAuthorship W2580497425A5040158605 @default.
- W2580497425 hasAuthorship W2580497425A5052684200 @default.
- W2580497425 hasAuthorship W2580497425A5069809093 @default.
- W2580497425 hasAuthorship W2580497425A5069919013 @default.
- W2580497425 hasAuthorship W2580497425A5076234152 @default.
- W2580497425 hasConcept C104317684 @default.
- W2580497425 hasConcept C124535831 @default.
- W2580497425 hasConcept C126322002 @default.
- W2580497425 hasConcept C128544194 @default.
- W2580497425 hasConcept C142724271 @default.
- W2580497425 hasConcept C143998085 @default.
- W2580497425 hasConcept C163763905 @default.
- W2580497425 hasConcept C177713679 @default.
- W2580497425 hasConcept C2777408962 @default.
- W2580497425 hasConcept C2779134260 @default.
- W2580497425 hasConcept C2781197716 @default.
- W2580497425 hasConcept C2908647359 @default.
- W2580497425 hasConcept C2911091166 @default.
- W2580497425 hasConcept C46111723 @default.
- W2580497425 hasConcept C55493867 @default.
- W2580497425 hasConcept C60644358 @default.
- W2580497425 hasConcept C71924100 @default.
- W2580497425 hasConcept C86803240 @default.
- W2580497425 hasConcept C99454951 @default.
- W2580497425 hasConceptScore W2580497425C104317684 @default.
- W2580497425 hasConceptScore W2580497425C124535831 @default.
- W2580497425 hasConceptScore W2580497425C126322002 @default.
- W2580497425 hasConceptScore W2580497425C128544194 @default.
- W2580497425 hasConceptScore W2580497425C142724271 @default.
- W2580497425 hasConceptScore W2580497425C143998085 @default.
- W2580497425 hasConceptScore W2580497425C163763905 @default.
- W2580497425 hasConceptScore W2580497425C177713679 @default.
- W2580497425 hasConceptScore W2580497425C2777408962 @default.
- W2580497425 hasConceptScore W2580497425C2779134260 @default.
- W2580497425 hasConceptScore W2580497425C2781197716 @default.
- W2580497425 hasConceptScore W2580497425C2908647359 @default.
- W2580497425 hasConceptScore W2580497425C2911091166 @default.
- W2580497425 hasConceptScore W2580497425C46111723 @default.
- W2580497425 hasConceptScore W2580497425C55493867 @default.
- W2580497425 hasConceptScore W2580497425C60644358 @default.
- W2580497425 hasConceptScore W2580497425C71924100 @default.
- W2580497425 hasConceptScore W2580497425C86803240 @default.
- W2580497425 hasConceptScore W2580497425C99454951 @default.
- W2580497425 hasOpenAccess W2580497425 @default.
- W2580497425 hasRelatedWork W1222046339 @default.
- W2580497425 hasRelatedWork W1489938260 @default.
- W2580497425 hasRelatedWork W1977411489 @default.
- W2580497425 hasRelatedWork W1998946253 @default.
- W2580497425 hasRelatedWork W2033876466 @default.
- W2580497425 hasRelatedWork W2076317384 @default.
- W2580497425 hasRelatedWork W2083285874 @default.
- W2580497425 hasRelatedWork W2322964753 @default.
- W2580497425 hasRelatedWork W2386366862 @default.
- W2580497425 hasRelatedWork W2415613079 @default.
- W2580497425 hasRelatedWork W2506787170 @default.
- W2580497425 hasRelatedWork W2527203520 @default.
- W2580497425 hasRelatedWork W2886274671 @default.
- W2580497425 hasRelatedWork W2951712302 @default.
- W2580497425 hasRelatedWork W3008784731 @default.
- W2580497425 hasRelatedWork W3080530199 @default.
- W2580497425 hasRelatedWork W79079033 @default.
- W2580497425 hasRelatedWork W889431833 @default.
- W2580497425 hasRelatedWork W2175949076 @default.
- W2580497425 hasRelatedWork W2548068858 @default.
- W2580497425 isParatext "false" @default.
- W2580497425 isRetracted "false" @default.
- W2580497425 magId "2580497425" @default.
- W2580497425 workType "article" @default.