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- W2580497688 abstract "Medicinal plants containing alkannin/shikonin and their derivatives have been used for wound healing treatment for years. Arnebia (Boraginaceae) species have these compounds in high quantity. Previous studies showed the root extract of Arnebia spec. and alkannin derivatives have wound healing, antiinflammatory, antitumoral, antibacterial and antifungal effects [1,2]. In this study, acetyl alkannin, the major naphthoquinone isolated from the roots n-hexane extract of Arnebia purpurea S. Erik & H. Sümbül which is an endemic species in Turkey have investigated in terms of its wound healing activity. Acetyl alkannin in PBS suspension (120 mg/kg, 0.1%) applied topically on both excision normal wound model and hydrocortisone-induced impaired wound model [3 – 4]. When our results were analyzed histopathologically (lymphocyte density, vascular proliferation, edema formation and fibrosis), acetyl alkannin applied groups had a statistically significant effect on all type wound healing phases compared with the control groups (p < 0.05, ANOVA test)." @default.
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- W2580497688 date "2015-11-25" @default.
- W2580497688 modified "2023-10-18" @default.
- W2580497688 title "The evaluation of wound healing potential of acetyl alkannin isolated from Arnebia purpurea" @default.
- W2580497688 doi "https://doi.org/10.1055/s-0035-1565391" @default.
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