Matches in SemOpenAlex for { <https://semopenalex.org/work/W2580529703> ?p ?o ?g. }
- W2580529703 endingPage "88" @default.
- W2580529703 startingPage "81" @default.
- W2580529703 abstract "There is extensive crosstalk between different Rho GTPases, including Cdc42, Rac1, and Rac2, and they can activate or inhibit the activity of each other. Dendritic cells express both Rac1 and Rac2. Due to posttranslational modification of lipid anchors, Rac1 localizes mainly to the plasma membrane whereas Rac2 localizes to the phagosomal membrane where it assembles the NADPH complex. Our recent study of primary immunodeficiency disease caused by mutations in the Cdc42 effector Wiskott-Aldrich syndrome protein (WASp) has shed light on the compensatory mechanisms between Rho GTPases and their effector proteins. WASp-deficient dendritic cells have increased localization and activity of Rac2 to the phagosomal membrane and this allows antigen to be presented on MHC class I molecules to activate cytotoxic CD8+ T cells. This study reveals an intricate balance between Rac2 and WASp signaling pathways and provides an example of compensatory pathways in cells devoid of the Cdc42 effector WASp." @default.
- W2580529703 created "2017-02-03" @default.
- W2580529703 creator A5012337343 @default.
- W2580529703 creator A5087698737 @default.
- W2580529703 date "2017-01-31" @default.
- W2580529703 modified "2023-10-12" @default.
- W2580529703 title "Activation of compensatory pathways via Rac2 in the absence of the Cdc42 effector Wiskott-Aldrich syndrome protein in Dendritic cells" @default.
- W2580529703 cites W1519766162 @default.
- W2580529703 cites W1581108390 @default.
- W2580529703 cites W1598564250 @default.
- W2580529703 cites W1829261443 @default.
- W2580529703 cites W1912537483 @default.
- W2580529703 cites W1948361600 @default.
- W2580529703 cites W1984967137 @default.
- W2580529703 cites W1990070411 @default.
- W2580529703 cites W1991549216 @default.
- W2580529703 cites W1996380677 @default.
- W2580529703 cites W1997537329 @default.
- W2580529703 cites W2002892911 @default.
- W2580529703 cites W2008416574 @default.
- W2580529703 cites W2010630254 @default.
- W2580529703 cites W2011756230 @default.
- W2580529703 cites W2012972393 @default.
- W2580529703 cites W2016253390 @default.
- W2580529703 cites W2022855448 @default.
- W2580529703 cites W2024891861 @default.
- W2580529703 cites W2027810531 @default.
- W2580529703 cites W2028940392 @default.
- W2580529703 cites W2031123547 @default.
- W2580529703 cites W2036145275 @default.
- W2580529703 cites W2042341745 @default.
- W2580529703 cites W2048148938 @default.
- W2580529703 cites W2049811440 @default.
- W2580529703 cites W2059161447 @default.
- W2580529703 cites W2063063649 @default.
- W2580529703 cites W2064771788 @default.
- W2580529703 cites W2066723778 @default.
- W2580529703 cites W2070638961 @default.
- W2580529703 cites W2072837740 @default.
- W2580529703 cites W2075238900 @default.
- W2580529703 cites W2076123445 @default.
- W2580529703 cites W2079896068 @default.
- W2580529703 cites W2085283900 @default.
- W2580529703 cites W2089472706 @default.
- W2580529703 cites W2090214720 @default.
- W2580529703 cites W2091901955 @default.
- W2580529703 cites W2095103973 @default.
- W2580529703 cites W2102037966 @default.
- W2580529703 cites W2107625881 @default.
- W2580529703 cites W2111528051 @default.
- W2580529703 cites W2117403796 @default.
- W2580529703 cites W2118060829 @default.
- W2580529703 cites W2126915765 @default.
- W2580529703 cites W2138048064 @default.
- W2580529703 cites W2139157614 @default.
- W2580529703 cites W2143601035 @default.
- W2580529703 cites W2144031609 @default.
- W2580529703 cites W2164396922 @default.
- W2580529703 cites W2165006836 @default.
- W2580529703 cites W2310376306 @default.
- W2580529703 cites W2345037133 @default.
- W2580529703 cites W2479943477 @default.
- W2580529703 cites W2489225126 @default.
- W2580529703 cites W2516462945 @default.
- W2580529703 cites W802212689 @default.
- W2580529703 doi "https://doi.org/10.1080/21541248.2016.1275363" @default.
- W2580529703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6380290" @default.
- W2580529703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28129089" @default.
- W2580529703 hasPublicationYear "2017" @default.
- W2580529703 type Work @default.
- W2580529703 sameAs 2580529703 @default.
- W2580529703 citedByCount "9" @default.
- W2580529703 countsByYear W25805297032018 @default.
- W2580529703 countsByYear W25805297032019 @default.
- W2580529703 countsByYear W25805297032020 @default.
- W2580529703 countsByYear W25805297032021 @default.
- W2580529703 countsByYear W25805297032023 @default.
- W2580529703 crossrefType "journal-article" @default.
- W2580529703 hasAuthorship W2580529703A5012337343 @default.
- W2580529703 hasAuthorship W2580529703A5087698737 @default.
- W2580529703 hasBestOaLocation W25805297031 @default.
- W2580529703 hasConcept C104317684 @default.
- W2580529703 hasConcept C142669718 @default.
- W2580529703 hasConcept C1491633281 @default.
- W2580529703 hasConcept C154317977 @default.
- W2580529703 hasConcept C170627219 @default.
- W2580529703 hasConcept C202751555 @default.
- W2580529703 hasConcept C203014093 @default.
- W2580529703 hasConcept C207332259 @default.
- W2580529703 hasConcept C207936829 @default.
- W2580529703 hasConcept C2778153459 @default.
- W2580529703 hasConcept C2778973524 @default.
- W2580529703 hasConcept C2779717556 @default.
- W2580529703 hasConcept C2780040266 @default.
- W2580529703 hasConcept C2780939953 @default.
- W2580529703 hasConcept C2909331102 @default.
- W2580529703 hasConcept C2993400109 @default.
- W2580529703 hasConcept C51785407 @default.