FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2580560146> ?p ?o ?g. }

• W2580560146 endingPage "18" @default.
• W2580560146 startingPage "1" @default.
• W2580560146 abstract "Research efforts targeting the identification of bladder cancer biomarkers have been extensive during the past decade. Investigations have been performed at the genome, transcriptome, proteome, and metabolome levels and outputs have started appearing including the sketching of disease molecular subtypes. Proteins are directly linked to cell phenotype hence they accumulate special interest as both biomarkers and therapeutic targets. Multiple technical challenges exist, of the main, being the protein concentration vast dynamic range and presence of proteins in modified forms. The scope of this review is to summarize the contribution of proteomics research in this quest of bladder cancer biomarkers. To obtain an unbiased and comprehensive overview, the scientific literature was searched for manuscripts describing proteomic studies on urothelial cancer from the last ten years and those including independent verification studies in urine, tissue and blood are briefly presented. General observations include: a) in most cases, suboptimal experimental design including healthy controls in biomarker discovery and frequently biomarker verification, is followed; b) variability in protein findings between studies can be observed, to some extent reflecting complexity of experimental approaches and proteome itself; c) consistently reported biomarkers include mainly plasma proteins and d) compilation of protein markers into diagnostic panels appears the most promising way forward. Two main avenues of research can now be foreseen: targeting integration of the existing disparate data with proteomic findings being placed in the context of existing knowledge on bladder cancer subtypes and in parallel, accumulation of clinical samples to support proper validation studies of promising marker combinations." @default.
• W2580560146 created "2017-02-03" @default.
• W2580560146 creator A5014263807 @default.
• W2580560146 creator A5024391183 @default.
• W2580560146 date "2017-01-27" @default.
• W2580560146 modified "2023-10-12" @default.
• W2580560146 title "Ten Years of Proteomics in Bladder Cancer: Progress and Future Directions" @default.
• W2580560146 cites W1480519071 @default.
• W2580560146 cites W1582788892 @default.
• W2580560146 cites W1938958967 @default.
• W2580560146 cites W1969120160 @default.
• W2580560146 cites W1969513066 @default.
• W2580560146 cites W1972447744 @default.
• W2580560146 cites W1974026630 @default.
• W2580560146 cites W1976485025 @default.
• W2580560146 cites W1996031455 @default.
• W2580560146 cites W1999861622 @default.
• W2580560146 cites W2001476013 @default.
• W2580560146 cites W2003103844 @default.
• W2580560146 cites W2012761580 @default.
• W2580560146 cites W2018410490 @default.
• W2580560146 cites W2020016182 @default.
• W2580560146 cites W2022534648 @default.
• W2580560146 cites W2029128218 @default.
• W2580560146 cites W2035633115 @default.
• W2580560146 cites W2043276694 @default.
• W2580560146 cites W2046283885 @default.
• W2580560146 cites W2050712934 @default.
• W2580560146 cites W2053095426 @default.
• W2580560146 cites W2054189670 @default.
• W2580560146 cites W2056308619 @default.
• W2580560146 cites W2061353399 @default.
• W2580560146 cites W2063844943 @default.
• W2580560146 cites W2067851786 @default.
• W2580560146 cites W2068140176 @default.
• W2580560146 cites W2071095150 @default.
• W2580560146 cites W2077569527 @default.
• W2580560146 cites W2078260688 @default.
• W2580560146 cites W2080183167 @default.
• W2580560146 cites W2087599883 @default.
• W2580560146 cites W2092909469 @default.
• W2580560146 cites W2094422890 @default.
• W2580560146 cites W2094458737 @default.
• W2580560146 cites W2094595904 @default.
• W2580560146 cites W2095387199 @default.
• W2580560146 cites W2095484897 @default.
• W2580560146 cites W2111778115 @default.
• W2580560146 cites W2116748469 @default.
• W2580560146 cites W2118164870 @default.
• W2580560146 cites W2121406339 @default.
• W2580560146 cites W2122030021 @default.
• W2580560146 cites W2123094509 @default.
• W2580560146 cites W2125770956 @default.
• W2580560146 cites W2126538910 @default.
• W2580560146 cites W2133038118 @default.
• W2580560146 cites W2133120086 @default.
• W2580560146 cites W2136272028 @default.
• W2580560146 cites W2139258705 @default.
• W2580560146 cites W2145281616 @default.
• W2580560146 cites W2145957085 @default.
• W2580560146 cites W2147652209 @default.
• W2580560146 cites W2153861174 @default.
• W2580560146 cites W2154065963 @default.
• W2580560146 cites W2154126507 @default.
• W2580560146 cites W2163738086 @default.
• W2580560146 cites W2195209480 @default.
• W2580560146 cites W2233973339 @default.
• W2580560146 cites W2252644942 @default.
• W2580560146 cites W2259792388 @default.
• W2580560146 cites W2273637195 @default.
• W2580560146 cites W2275680691 @default.
• W2580560146 cites W2301258743 @default.
• W2580560146 cites W2328605991 @default.
• W2580560146 cites W2469074081 @default.
• W2580560146 cites W2469638476 @default.
• W2580560146 cites W2502033100 @default.
• W2580560146 cites W2556766021 @default.
• W2580560146 cites W4211115520 @default.
• W2580560146 doi "https://doi.org/10.3233/blc-160073" @default.
• W2580560146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5271479" @default.
• W2580560146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28149930" @default.
• W2580560146 hasPublicationYear "2017" @default.
• W2580560146 type Work @default.
• W2580560146 sameAs 2580560146 @default.
• W2580560146 citedByCount "18" @default.
• W2580560146 countsByYear W25805601462017 @default.
• W2580560146 countsByYear W25805601462018 @default.
• W2580560146 countsByYear W25805601462019 @default.
• W2580560146 countsByYear W25805601462020 @default.
• W2580560146 countsByYear W25805601462021 @default.
• W2580560146 countsByYear W25805601462022 @default.
• W2580560146 countsByYear W25805601462023 @default.
• W2580560146 crossrefType "journal-article" @default.
• W2580560146 hasAuthorship W2580560146A5014263807 @default.
• W2580560146 hasAuthorship W2580560146A5024391183 @default.
• W2580560146 hasBestOaLocation W25805601461 @default.
• W2580560146 hasConcept C104317684 @default.
• W2580560146 hasConcept C104397665 @default.

• next