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• W2580716668 abstract "Abstract To identify genomic markers associated with the response to neoadjuvant chemotherapy (NACT) in patients with cervical cancer, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. A total of 596 patients with stage IA2-IIIB cervical cancer were enrolled in this study. One single nucleotide polymorphism (SNP) (rs6812281, per allele OR = 2.37, P = 9.0 × 10 −9 ) located at 4q34.3 reached GWAS significance ( P < 5.0 × 10 −8 ). Another three SNPs, rs4590782 (10q26.2, P = 1.59 × 10 −5 , per allele OR = 0.48), rs1742101 (14q32.11, P = 7.11 × 10 −6 , per allele OR = 0.52), and rs1364121 (16q23.3, P = 3.15 × 10 −6 , per allele OR = 1.98), exhibited strong evidence of associations with response to neoadjuvant chemotherapy. Patients with a C allele (CT + CC) of rs4590782 had better 5-year overall survival rates (82.9% vs. 75.8%, P = 0.083) and 5-year disease-free survival rate (80.8% vs. 72.7%, P = 0.021) than those without a C allele. Our findings help to characterize the genetic etiology of the response to neoadjuvant chemotherapy in patients with cervical cancer." @default.
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• W2580716668 date "2017-01-25" @default.
• W2580716668 modified "2023-10-09" @default.
• W2580716668 title "Genome-wide association study identifies four SNPs associated with response to platinum-based neoadjuvant chemotherapy for cervical cancer" @default.
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• W2580716668 doi "https://doi.org/10.1038/srep41103" @default.
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