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- W2580760842 abstract "We describe a methodology for quick development of fluorescent probes with the desired potency for the target of interest by using a method of parallel synthesis, termed as Parallel Fluorescent Probe Synthesis (Parallel-FPS). BODIPY FL propionic acid 1 is a widely used fluorophore, but it is difficult to prepare a large amount of 1, which hinders its use in parallel synthesis. Optimization of a synthetic scheme enabled us to obtain 50g of 1 in one batch. With this large quantity of 1 in hand, we performed Parallel-FPS of BODIPY FL-labeled ligands for estrogen related receptor-α (ERRα). An initial trial of the parallel synthesis with various linkers provided a potent ligand for ERRα (Reporter IC50=80nM), demonstrating the usefulness of Parallel-FPS." @default.
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- W2580760842 date "2017-03-01" @default.
- W2580760842 modified "2023-09-26" @default.
- W2580760842 title "Parallel fluorescent probe synthesis based on the large-scale preparation of BODIPY FL propionic acid" @default.
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- W2580760842 doi "https://doi.org/10.1016/j.bmcl.2017.01.076" @default.
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