FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2580764146> ?p ?o ?g. }

• W2580764146 endingPage "178" @default.
• W2580764146 startingPage "172" @default.
• W2580764146 abstract "Initiation of cytochrome P-450 (CYP)-inducing anticonvulsant medications during warfarin therapy may decrease anticoagulant effect and necessitate frequent warfarin dose adjustments to maintain therapeutic response measured by the international normalized ratio (INR). Clinical information regarding interactions between warfarin and these medications is limited. This study investigated warfarin dose and INR response following CYP-inducing anticonvulsant initiation among chronic warfarin users. This retrospective, pre-post study included patients ≥18 years who were receiving chronic warfarin therapy and who initiated carbamazepine, oxcarbazepine, phenobarbital, or phenytoin between January 1, 2006, and December 31, 2013. Mean weekly warfarin dose/INR ratio and mean weekly warfarin dose were compared in the 90 days pre- and days post-anticonvulsant initiation periods. Of the 57 included patients, 34 (60%), 15 (26%), 6 (11%), and 2 (3%) patients purchased a prescription for carbamazepine, phenytoin, oxcarbazepine, and phenobarbital, respectively. Mean age was 70 years, 59% were female, and the majority were receiving chronic warfarin therapy for atrial fibrillation (39%) or venous thromboembolism (26%). The ratio of mean warfarin dose and INR increased significantly between the pre- and post-anticonvulsant initiation periods (from 13 mg/INR to 18 mg/INR, respectively, P ≤ .001) as did the mean weekly warfarin dose (from 33 mg to 37 mg, P = <.001). Warfarin dose and dose/INR ratio significantly increased after carbamazepine initiation (both P < .001), while oxcarbazepine, phenobarbital, and phenytoin initiation did not significantly affect warfarin dosing. Our results support the presence of a clinically meaningful interaction between warfarin and carbamazepine. Frequent INR monitoring and warfarin dose escalation are recommended in this setting." @default.
• W2580764146 created "2017-02-03" @default.
• W2580764146 creator A5014865134 @default.
• W2580764146 creator A5023024177 @default.
• W2580764146 creator A5083325108 @default.
• W2580764146 creator A5084849999 @default.
• W2580764146 creator A5087901835 @default.
• W2580764146 date "2017-01-25" @default.
• W2580764146 modified "2023-10-14" @default.
• W2580764146 title "Warfarin Interaction With Hepatic Cytochrome P-450 Enzyme-Inducing Anticonvulsants" @default.
• W2580764146 cites W1969443214 @default.
• W2580764146 cites W1971165963 @default.
• W2580764146 cites W1978356885 @default.
• W2580764146 cites W1985805985 @default.
• W2580764146 cites W1992701784 @default.
• W2580764146 cites W1998354077 @default.
• W2580764146 cites W2030033405 @default.
• W2580764146 cites W2058019190 @default.
• W2580764146 cites W2061354537 @default.
• W2580764146 cites W2061520161 @default.
• W2580764146 cites W2065847144 @default.
• W2580764146 cites W2092291771 @default.
• W2580764146 cites W2112550499 @default.
• W2580764146 cites W2123298478 @default.
• W2580764146 cites W2130908779 @default.
• W2580764146 cites W2156687558 @default.
• W2580764146 cites W2269923173 @default.
• W2580764146 cites W227721353 @default.
• W2580764146 cites W2444366053 @default.
• W2580764146 cites W81697156 @default.
• W2580764146 cites W119260331 @default.
• W2580764146 doi "https://doi.org/10.1177/1076029616687849" @default.
• W2580764146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6714638" @default.
• W2580764146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28118749" @default.
• W2580764146 hasPublicationYear "2017" @default.
• W2580764146 type Work @default.
• W2580764146 sameAs 2580764146 @default.
• W2580764146 citedByCount "12" @default.
• W2580764146 countsByYear W25807641462017 @default.
• W2580764146 countsByYear W25807641462018 @default.
• W2580764146 countsByYear W25807641462020 @default.
• W2580764146 countsByYear W25807641462021 @default.
• W2580764146 countsByYear W25807641462022 @default.
• W2580764146 countsByYear W25807641462023 @default.
• W2580764146 crossrefType "journal-article" @default.
• W2580764146 hasAuthorship W2580764146A5014865134 @default.
• W2580764146 hasAuthorship W2580764146A5023024177 @default.
• W2580764146 hasAuthorship W2580764146A5083325108 @default.
• W2580764146 hasAuthorship W2580764146A5084849999 @default.
• W2580764146 hasAuthorship W2580764146A5087901835 @default.
• W2580764146 hasBestOaLocation W25807641461 @default.
• W2580764146 hasConcept C112705442 @default.
• W2580764146 hasConcept C118552586 @default.
• W2580764146 hasConcept C126322002 @default.
• W2580764146 hasConcept C2775858608 @default.
• W2580764146 hasConcept C2776301958 @default.
• W2580764146 hasConcept C2777288759 @default.
• W2580764146 hasConcept C2778186239 @default.
• W2580764146 hasConcept C2778337148 @default.
• W2580764146 hasConcept C2778793413 @default.
• W2580764146 hasConcept C2779161974 @default.
• W2580764146 hasConcept C2779253243 @default.
• W2580764146 hasConcept C2781176495 @default.
• W2580764146 hasConcept C27924281 @default.
• W2580764146 hasConcept C3946865 @default.
• W2580764146 hasConcept C42219234 @default.
• W2580764146 hasConcept C526171541 @default.
• W2580764146 hasConcept C62231903 @default.
• W2580764146 hasConcept C71924100 @default.
• W2580764146 hasConcept C97320921 @default.
• W2580764146 hasConcept C98274493 @default.
• W2580764146 hasConceptScore W2580764146C112705442 @default.
• W2580764146 hasConceptScore W2580764146C118552586 @default.
• W2580764146 hasConceptScore W2580764146C126322002 @default.
• W2580764146 hasConceptScore W2580764146C2775858608 @default.
• W2580764146 hasConceptScore W2580764146C2776301958 @default.
• W2580764146 hasConceptScore W2580764146C2777288759 @default.
• W2580764146 hasConceptScore W2580764146C2778186239 @default.
• W2580764146 hasConceptScore W2580764146C2778337148 @default.
• W2580764146 hasConceptScore W2580764146C2778793413 @default.
• W2580764146 hasConceptScore W2580764146C2779161974 @default.
• W2580764146 hasConceptScore W2580764146C2779253243 @default.
• W2580764146 hasConceptScore W2580764146C2781176495 @default.
• W2580764146 hasConceptScore W2580764146C27924281 @default.
• W2580764146 hasConceptScore W2580764146C3946865 @default.
• W2580764146 hasConceptScore W2580764146C42219234 @default.
• W2580764146 hasConceptScore W2580764146C526171541 @default.
• W2580764146 hasConceptScore W2580764146C62231903 @default.
• W2580764146 hasConceptScore W2580764146C71924100 @default.
• W2580764146 hasConceptScore W2580764146C97320921 @default.
• W2580764146 hasConceptScore W2580764146C98274493 @default.
• W2580764146 hasIssue "1" @default.
• W2580764146 hasLocation W25807641461 @default.
• W2580764146 hasLocation W25807641462 @default.
• W2580764146 hasLocation W25807641463 @default.
• W2580764146 hasLocation W25807641464 @default.
• W2580764146 hasOpenAccess W2580764146 @default.
• W2580764146 hasPrimaryLocation W25807641461 @default.

• next