Matches in SemOpenAlex for { <https://semopenalex.org/work/W2580821999> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2580821999 abstract "Down Syndrome is a common disorder which causes intellectual disability among other symptoms. To date, no treatment exists for the learning difficulties associated with Down Syndrome. However, the pharmaceutical drug memantine has been shown to improve learning ability in a Down Syndrome model of mice (Ts65Dn) exposed to Context Fear Conditioning (CFC), an existing technique used in determining the extent of learning capability of mice. While the effect of memantine on learning capability in Ts65Dn mice is significant, the biological mechanism responsible for restoration of learning capability by memantine is poorly understood. One possible way to characterize this mechanism is by analyzing the neural protein profile data of normal and Down Syndrome mice with and without memantine treatment. In this work, we use a series of linear support vector machines to model the differential expression of 77 proteins obtained from the nuclear cortex of normal and Ts65Dn mice, with and without memantine treatment and with and without CFC stimulation. We use feature selection by weight threshold to select those proteins which play a significant role in characterizing each model. Per our findings, these subsets of proteins can be used to build more accurate classification models of the data than those subsets chosen using unsupervised learning or statistical analyses in previous studies. We recommend that the subsets of proteins selected using our proposed method be utilized in further biological study aiming to understand the effects of memantine on learning restoration." @default.
- W2580821999 created "2017-02-03" @default.
- W2580821999 creator A5048150961 @default.
- W2580821999 creator A5087432023 @default.
- W2580821999 date "2017-05-01" @default.
- W2580821999 modified "2023-09-27" @default.
- W2580821999 title "A support vector machine approach to identification of proteins relevant to learning in a mouse model of Down Syndrome" @default.
- W2580821999 cites W1562896067 @default.
- W2580821999 cites W1604956938 @default.
- W2580821999 cites W1964772923 @default.
- W2580821999 cites W1992811119 @default.
- W2580821999 cites W2007978808 @default.
- W2580821999 cites W2067777223 @default.
- W2580821999 cites W2079505595 @default.
- W2580821999 cites W2101626807 @default.
- W2580821999 cites W2122913279 @default.
- W2580821999 cites W2139212933 @default.
- W2580821999 cites W2170085655 @default.
- W2580821999 cites W4247827554 @default.
- W2580821999 doi "https://doi.org/10.1109/ijcnn.2017.7966282" @default.
- W2580821999 hasPublicationYear "2017" @default.
- W2580821999 type Work @default.
- W2580821999 sameAs 2580821999 @default.
- W2580821999 citedByCount "4" @default.
- W2580821999 countsByYear W25808219992018 @default.
- W2580821999 countsByYear W25808219992019 @default.
- W2580821999 countsByYear W25808219992020 @default.
- W2580821999 crossrefType "proceedings-article" @default.
- W2580821999 hasAuthorship W2580821999A5048150961 @default.
- W2580821999 hasAuthorship W2580821999A5087432023 @default.
- W2580821999 hasBestOaLocation W25808219992 @default.
- W2580821999 hasConcept C111472728 @default.
- W2580821999 hasConcept C116834253 @default.
- W2580821999 hasConcept C119857082 @default.
- W2580821999 hasConcept C12267149 @default.
- W2580821999 hasConcept C126322002 @default.
- W2580821999 hasConcept C138885662 @default.
- W2580821999 hasConcept C148483581 @default.
- W2580821999 hasConcept C151730666 @default.
- W2580821999 hasConcept C154945302 @default.
- W2580821999 hasConcept C15744967 @default.
- W2580821999 hasConcept C169760540 @default.
- W2580821999 hasConcept C170493617 @default.
- W2580821999 hasConcept C2779343474 @default.
- W2580821999 hasConcept C2779484449 @default.
- W2580821999 hasConcept C41008148 @default.
- W2580821999 hasConcept C59822182 @default.
- W2580821999 hasConcept C67018056 @default.
- W2580821999 hasConcept C71924100 @default.
- W2580821999 hasConcept C86803240 @default.
- W2580821999 hasConcept C89611455 @default.
- W2580821999 hasConceptScore W2580821999C111472728 @default.
- W2580821999 hasConceptScore W2580821999C116834253 @default.
- W2580821999 hasConceptScore W2580821999C119857082 @default.
- W2580821999 hasConceptScore W2580821999C12267149 @default.
- W2580821999 hasConceptScore W2580821999C126322002 @default.
- W2580821999 hasConceptScore W2580821999C138885662 @default.
- W2580821999 hasConceptScore W2580821999C148483581 @default.
- W2580821999 hasConceptScore W2580821999C151730666 @default.
- W2580821999 hasConceptScore W2580821999C154945302 @default.
- W2580821999 hasConceptScore W2580821999C15744967 @default.
- W2580821999 hasConceptScore W2580821999C169760540 @default.
- W2580821999 hasConceptScore W2580821999C170493617 @default.
- W2580821999 hasConceptScore W2580821999C2779343474 @default.
- W2580821999 hasConceptScore W2580821999C2779484449 @default.
- W2580821999 hasConceptScore W2580821999C41008148 @default.
- W2580821999 hasConceptScore W2580821999C59822182 @default.
- W2580821999 hasConceptScore W2580821999C67018056 @default.
- W2580821999 hasConceptScore W2580821999C71924100 @default.
- W2580821999 hasConceptScore W2580821999C86803240 @default.
- W2580821999 hasConceptScore W2580821999C89611455 @default.
- W2580821999 hasLocation W25808219991 @default.
- W2580821999 hasLocation W25808219992 @default.
- W2580821999 hasLocation W25808219993 @default.
- W2580821999 hasOpenAccess W2580821999 @default.
- W2580821999 hasPrimaryLocation W25808219991 @default.
- W2580821999 hasRelatedWork W1996541855 @default.
- W2580821999 hasRelatedWork W2735962158 @default.
- W2580821999 hasRelatedWork W2937631562 @default.
- W2580821999 hasRelatedWork W2985924212 @default.
- W2580821999 hasRelatedWork W3034132578 @default.
- W2580821999 hasRelatedWork W3195168932 @default.
- W2580821999 hasRelatedWork W3200179079 @default.
- W2580821999 hasRelatedWork W4288767684 @default.
- W2580821999 hasRelatedWork W4293525103 @default.
- W2580821999 hasRelatedWork W2345184372 @default.
- W2580821999 isParatext "false" @default.
- W2580821999 isRetracted "false" @default.
- W2580821999 magId "2580821999" @default.
- W2580821999 workType "article" @default.