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• W2580929144 abstract "Astrocytes play crucial roles in brain homeostasis and are emerging as regulatory elements of neuronal and synaptic physiology by responding to neurotransmitters with Ca 2+ elevations and releasing gliotransmitters that activate neuronal receptors. Aging involves neuronal and astrocytic alterations, being considered risk factor for neurodegenerative diseases. Most evidence of the astrocyte–neuron signaling is derived from studies with young animals; however, the features of astrocyte–neuron signaling in adult and aging brain remain largely unknown. We have investigated the existence and properties of astrocyte–neuron signaling in physiologically and pathologically aging mouse hippocampal and cortical slices at different lifetime points (0.5 to 20 month‐old animals). We found that astrocytes preserved their ability to express spontaneous and neurotransmitter‐dependent intracellular Ca 2+ signals from juvenile to aging brains. Likewise, resting levels of gliotransmission, assessed by neuronal NMDAR activation by glutamate released from astrocytes, were largely preserved with similar properties in all tested age groups, but DHPG‐induced gliotransmission was reduced in aged mice. In contrast, gliotransmission was enhanced in the APP/PS1 mouse model of Alzheimer's disease, indicating a dysregulation of astrocyte–neuron signaling in pathological conditions. Disruption of the astrocytic IP 3 R2 mediated‐signaling, which is required for neurotransmitter‐induced astrocyte Ca 2+ signals and gliotransmission, boosted the progression of amyloid plaque deposits and synaptic plasticity impairments in APP/PS1 mice at early stages of the disease. Therefore, astrocyte–neuron interaction is a fundamental signaling, largely conserved in the adult and aging brain of healthy animals, but it is altered in Alzheimer's disease, suggesting that dysfunctions of astrocyte Ca 2+ physiology may contribute to this neurodegenerative disease. GLIA 2017 GLIA 2017;65:569–580" @default.
• W2580929144 created "2017-02-03" @default.
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• W2580929144 date "2017-01-28" @default.
• W2580929144 modified "2023-10-11" @default.
• W2580929144 title "Neuron-astrocyte signaling is preserved in the aging brain" @default.
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• W2580929144 doi "https://doi.org/10.1002/glia.23112" @default.
• W2580929144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5314210" @default.
• W2580929144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28130845" @default.
• W2580929144 hasPublicationYear "2017" @default.
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