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• W2580936711 abstract "Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members of the human gut microbiome. This decrease sensitizes bacteria towards oxidative stress, reduces colonization and attenuates persister cell and biofilm formation, suggesting that mesalamine aids in diminishing the capacity of bacteria to persist within chronically inflamed environments." @default.
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• W2580936711 date "2017-01-23" @default.
• W2580936711 modified "2023-10-16" @default.
• W2580936711 title "The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation" @default.
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• W2580936711 doi "https://doi.org/10.1038/nmicrobiol.2016.267" @default.
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