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- W2580942016 abstract "Abstract Wnt signaling is a critical component during embryonic development and also plays an important role in regulating adult tissue homeostasis. Abnormal activation of Wnt signaling has been implicated in many cancers, while reduced activity of Wnt signaling leads to poor wound healing and structural formations. Thus, extensive efforts have been focused on developing small molecules that have potential to either inhibit or activate the pathway, hoping these molecules can offer leads for novel approaches in treating different human diseases. Many small‐molecule inhibitors specifically target various elements, such as Frizzled, Disheveled, Porcupine, or Tankyrase, within the Wnt signaling pathways. These small molecules not only have the potential to be further developed as therapeutic reagents, but they may also be used as chemical probes to dissect the underlying mechanism of the Wnt signaling pathways. Therefore, their respective mechanisms and effective dosages are highly pertinent. Aiming to provide an overview of those molecules in a concise, easy‐to‐use manner, we summarize and organize the current research on them so that it may be helpful for utilization in different studies." @default.
- W2580942016 created "2017-02-03" @default.
- W2580942016 creator A5049911426 @default.
- W2580942016 creator A5083419129 @default.
- W2580942016 date "2017-02-11" @default.
- W2580942016 modified "2023-09-27" @default.
- W2580942016 title "Modulating the wnt signaling pathway with small molecules" @default.
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- W2580942016 doi "https://doi.org/10.1002/pro.3122" @default.
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