FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2581070713> ?p ?o ?g. }

• W2581070713 endingPage "L499" @default.
• W2581070713 startingPage "L488" @default.
• W2581070713 abstract "Pulmonary fibrosis contributes to morbidity and mortality in a range of diseases, and there are no approved therapies for reversing its progression. To understand the mechanisms underlying pulmonary fibrosis and assess potential therapies, mouse models are central to basic and translational research. Unfortunately, metrics commonly used to assess murine pulmonary fibrosis require animals to be grouped and euthanized, increasing experimental difficulty and cost. We examined the ability of magnetic resonance imaging (MRI) to noninvasively assess lung fibrosis progression and resolution in a doxycycline (Dox) regulatable, transgenic mouse model that overexpresses transforming growth factor-α (TGF-α) under control of a lung-epithelial-specific promoter. During 7 wk of Dox treatment, fibrotic lesions were readily observed as high-signal tissue. Mean weighted signal and percent signal volume were found to be the most robust MRI-derived measures of fibrosis, and these metrics correlated significantly with pleural thickness, histology scores, and hydroxyproline content (R = 0.75-0.89). When applied longitudinally, percent high signal volume increased by 1.5% wk-1 (P < 0.001) and mean weighted signal increased at a rate of 0.0065 wk-1 (P = 0.0062). Following Dox treatment, lesions partially resolved, with percent high signal volume decreasing by -3.2% wk-1 (P = 0.0034) and weighted mean signal decreasing at -0.015 wk-1 (P = 0.0028). Additionally, longitudinal MRI revealed dynamic remodeling in a subset of lesions, a previously unobserved behavior in this model. These results demonstrate MRI can noninvasively assess experimental lung fibrosis progression and resolution and provide unique insights into its pathobiology." @default.
• W2581070713 created "2017-02-03" @default.
• W2581070713 creator A5009622151 @default.
• W2581070713 creator A5009824254 @default.
• W2581070713 creator A5020592001 @default.
• W2581070713 creator A5049632059 @default.
• W2581070713 creator A5057850897 @default.
• W2581070713 creator A5059324861 @default.
• W2581070713 creator A5061515285 @default.
• W2581070713 creator A5076439272 @default.
• W2581070713 date "2017-04-01" @default.
• W2581070713 modified "2023-10-18" @default.
• W2581070713 title "Magnetic resonance imaging of disease progression and resolution in a transgenic mouse model of pulmonary fibrosis" @default.
• W2581070713 cites W1593223298 @default.
• W2581070713 cites W1596712642 @default.
• W2581070713 cites W1849412223 @default.
• W2581070713 cites W1925481226 @default.
• W2581070713 cites W1974102437 @default.
• W2581070713 cites W1978312054 @default.
• W2581070713 cites W1988514106 @default.
• W2581070713 cites W1990937647 @default.
• W2581070713 cites W1993174637 @default.
• W2581070713 cites W1997699922 @default.
• W2581070713 cites W2004777084 @default.
• W2581070713 cites W2007697878 @default.
• W2581070713 cites W2008277917 @default.
• W2581070713 cites W2013316972 @default.
• W2581070713 cites W2013426785 @default.
• W2581070713 cites W2022660561 @default.
• W2581070713 cites W2023464004 @default.
• W2581070713 cites W2023883998 @default.
• W2581070713 cites W2024703667 @default.
• W2581070713 cites W2047261685 @default.
• W2581070713 cites W2054017711 @default.
• W2581070713 cites W2059171065 @default.
• W2581070713 cites W2069534609 @default.
• W2581070713 cites W2078216625 @default.
• W2581070713 cites W2087585030 @default.
• W2581070713 cites W2088298434 @default.
• W2581070713 cites W2091719438 @default.
• W2581070713 cites W2094440707 @default.
• W2581070713 cites W2100020120 @default.
• W2581070713 cites W2114333816 @default.
• W2581070713 cites W2120098653 @default.
• W2581070713 cites W2126011452 @default.
• W2581070713 cites W2127079647 @default.
• W2581070713 cites W2127416067 @default.
• W2581070713 cites W2136613707 @default.
• W2581070713 cites W2136801875 @default.
• W2581070713 cites W2138871107 @default.
• W2581070713 cites W2139728410 @default.
• W2581070713 cites W2140839448 @default.
• W2581070713 cites W2159127259 @default.
• W2581070713 cites W2166205211 @default.
• W2581070713 cites W2166791132 @default.
• W2581070713 cites W2168666423 @default.
• W2581070713 cites W2170701567 @default.
• W2581070713 cites W2172628686 @default.
• W2581070713 cites W2294818882 @default.
• W2581070713 cites W2318544461 @default.
• W2581070713 cites W2341948006 @default.
• W2581070713 cites W2413096372 @default.
• W2581070713 cites W639212480 @default.
• W2581070713 doi "https://doi.org/10.1152/ajplung.00458.2016" @default.
• W2581070713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5407091" @default.
• W2581070713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28130263" @default.
• W2581070713 hasPublicationYear "2017" @default.
• W2581070713 type Work @default.
• W2581070713 sameAs 2581070713 @default.
• W2581070713 citedByCount "5" @default.
• W2581070713 countsByYear W25810707132019 @default.
• W2581070713 countsByYear W25810707132020 @default.
• W2581070713 countsByYear W25810707132021 @default.
• W2581070713 crossrefType "journal-article" @default.
• W2581070713 hasAuthorship W2581070713A5009622151 @default.
• W2581070713 hasAuthorship W2581070713A5009824254 @default.
• W2581070713 hasAuthorship W2581070713A5020592001 @default.
• W2581070713 hasAuthorship W2581070713A5049632059 @default.
• W2581070713 hasAuthorship W2581070713A5057850897 @default.
• W2581070713 hasAuthorship W2581070713A5059324861 @default.
• W2581070713 hasAuthorship W2581070713A5061515285 @default.
• W2581070713 hasAuthorship W2581070713A5076439272 @default.
• W2581070713 hasBestOaLocation W25810707131 @default.
• W2581070713 hasConcept C102230213 @default.
• W2581070713 hasConcept C104317684 @default.
• W2581070713 hasConcept C126322002 @default.
• W2581070713 hasConcept C126838900 @default.
• W2581070713 hasConcept C141035611 @default.
• W2581070713 hasConcept C142724271 @default.
• W2581070713 hasConcept C143409427 @default.
• W2581070713 hasConcept C2777714996 @default.
• W2581070713 hasConcept C2779797417 @default.
• W2581070713 hasConcept C2780559512 @default.
• W2581070713 hasConcept C2781244666 @default.
• W2581070713 hasConcept C55493867 @default.
• W2581070713 hasConcept C71924100 @default.
• W2581070713 hasConcept C86803240 @default.
• W2581070713 hasConceptScore W2581070713C102230213 @default.

• next