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- W2581163692 abstract "Background: EGFR tyrosine kinase inhibitors (TKIs) are widely used for advanced nonsmall cell lung cancer (NSCLC) patients with a sensitizing EGFR mutation and provide a promising treatment strategy. However, acquired resistance to EGFR-TKIs restricts their application. The mechanisms underlying acquired resistance to TKIs have been explored and Phosphoinositide 3- kinase (PI3K)/Akt/mTOR pathway plays a very important role in NSCLC development as well as EGFR-TKI resistance. Polyphyllin II(PP II) is the main steroidal saponin constituent which derives from the root of Paris polychylia. Keywords: PI3K, drug-resistance, gefitinib, NSCLC, polyphyllin, apoptosis." @default.
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- W2581163692 date "2017-04-18" @default.
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- W2581163692 title "Polyphyllin II Restores Sensitization of the Resistance of PC-9/ZD Cells to Gefitinib by a Negative Regulation of the PI3K/Akt/mTOR Signaling Pathway" @default.
- W2581163692 doi "https://doi.org/10.2174/1568009616666161213141608" @default.
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