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• W2581417117 endingPage "kfw255" @default.
• W2581417117 startingPage "kfw255" @default.
• W2581417117 abstract "In cigarette smokers endothelial dysfunction, measured by flow-mediated dilation (FMD), precedes cardiovascular disease (CVD) and can be improved by supplementation with n - 3 polyunsaturated fatty acids (PUFAs). We developed a mouse model of cigarette smoke (CS)-induced endothelial dysfunction that resembles impaired FMD observed in human cigarette smokers and investigated the mechanism by which n - 3 PUFAs mediate vasoprotection. We hypothesized that loss of nitric oxide (NO)-dependent vasodilation in CS-exposed mice would be prevented by dietary n - 3 PUFAs via a decrease in oxidative stress. C57BL/6 mice were fed a chow or n - 3 PUFA diet for 8 weeks and then exposed to mainstream CS or filtered air for 5 days, 2 h/day. Mesenteric arterioles were preconstricted with U46619 and dilated by stepwise increases in pressure (0-40 mmHg), resulting in increases in flow, ± inhibitor of NO production or antioxidant, Tempol. Markers of oxidative stress were measured in lung and heart. CS-exposed mice on a chow diet had impaired FMD, resulting from loss of NO-dependent dilation, compared with air exposed mice. Tempol restored FMD by normalizing NO-dependent dilation and increasing NO-independent dilation. CS-exposed mice on the n - 3 PUFA diet had normal FMD, resulting from a significant increase in NO-independent dilation, compared with CS-exposed mice on a chow diet. Furthermore, n - 3 PUFAs decreased two CS-induced markers of oxidative stress, 8-epiprostaglandin-F2α levels and heme oxygenase-1 mRNA, and significantly attenuated CS-induced cytochrome P4501A1 mRNA expression. These data demonstrate that dietary n - 3 PUFAs can protect against CS-induced vascular dysfunction via multiple mechanisms, including increasing NO-independent vasodilation and decreasing oxidative stress." @default.
• W2581417117 created "2017-02-03" @default.
• W2581417117 creator A5027459975 @default.
• W2581417117 creator A5037357023 @default.
• W2581417117 creator A5062356563 @default.
• W2581417117 date "2017-01-22" @default.
• W2581417117 modified "2023-09-27" @default.
• W2581417117 title "Omega-3 Polyunsaturated Fatty Acids Protect against Cigarette Smoke-Induced Oxidative Stress and Vascular Dysfunction" @default.
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• W2581417117 doi "https://doi.org/10.1093/toxsci/kfw255" @default.
• W2581417117 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6075584" @default.
• W2581417117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28115642" @default.
• W2581417117 hasPublicationYear "2017" @default.
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