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- W2581539422 endingPage "20160182" @default.
- W2581539422 startingPage "20160182" @default.
- W2581539422 abstract "Elongation factors Tu (EF-Tu) and SelB are translational GTPases that deliver aminoacyl-tRNAs (aa-tRNAs) to the ribosome. In each canonical round of translation elongation, aa-tRNAs, assisted by EF-Tu, decode mRNA codons and insert the respective amino acid into the growing peptide chain. Stop codons usually lead to translation termination; however, in special cases UGA codons are recoded to selenocysteine (Sec) with the help of SelB. Recruitment of EF-Tu and SelB together with their respective aa-tRNAs to the ribosome is a multistep process. In this review, we summarize recent progress in understanding the role of ribosome dynamics in aa-tRNA selection. We describe the path to correct codon recognition by canonical elongator aa-tRNA and Sec-tRNA Sec and discuss the local and global rearrangements of the ribosome in response to correct and incorrect aa-tRNAs. We present the mechanisms of GTPase activation and GTP hydrolysis of EF-Tu and SelB and summarize what is known about the accommodation of aa-tRNA on the ribosome after its release from the elongation factor. We show how ribosome dynamics ensures high selectivity for the cognate aa-tRNA and suggest that conformational fluctuations, induced fit and kinetic discrimination play major roles in maintaining the speed and fidelity of translation. This article is part of the themed issue ‘Perspectives on the ribosome’." @default.
- W2581539422 created "2017-02-03" @default.
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- W2581539422 creator A5028476493 @default.
- W2581539422 creator A5041824154 @default.
- W2581539422 creator A5050363682 @default.
- W2581539422 date "2017-03-19" @default.
- W2581539422 modified "2023-10-12" @default.
- W2581539422 title "Ribosome dynamics during decoding" @default.
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- W2581539422 doi "https://doi.org/10.1098/rstb.2016.0182" @default.
- W2581539422 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5311926" @default.
- W2581539422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28138068" @default.
- W2581539422 hasPublicationYear "2017" @default.
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