FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W258154277> ?p ?o ?g. }

• W258154277 endingPage "218" @default.
• W258154277 startingPage "210" @default.
• W258154277 abstract "The purpose of the present study was to test the prediction that the unique manifestation of chemotherapeutic-induced peripheral neuropathy (CIPN) would be reflected in a specific pattern of changes in the regulation of the intracellular Ca(2+) concentration ([Ca(2+)]i) in subpopulations of cutaneous neurons. To test this prediction, we characterized the pattern of changes in mechanical nociceptive threshold associated with paclitaxel administration (2mg/kg, iv, every other day for four days), as well as the impact of target of innervation and paclitaxel treatment on the regulation of [Ca(2+)]i in subpopulations of putative nociceptive and non-nociceptive neurons. Neurons innervating the glabrous and hairy skin of the hindpaw as well as the thigh were identified with retrograde tracers, and fura-2 was used to assess changes in [Ca(2+)]i. Paclitaxel was associated with a persistent decrease in mechanical nociceptive threshold in response to stimuli applied to the glabrous skin of the hindpaw, but not the hairy skin of the hindpaw or the thigh. However, in both putative nociceptive and non-nociceptive neurons, resting [Ca(2+)]i was significantly lower in neurons innervating the thigh after treatment. The magnitude of the depolarization-evoked Ca(2+) transient was also lower in putative non-nociceptive thigh neurons. More interestingly, while paclitaxel had no detectable influence on either resting or depolarization-evoked Ca(2+) transients in putative non-nociceptive neurons, in putative nociceptive neurons there was a subpopulation-specific decrease in the duration of the evoked Ca(2+) transient that was largely restricted to neurons innervating the glabrous skin. These results suggest that peripheral nerve length alone, does not account for the selective distribution of CIPN symptoms. Rather, they suggest the symptoms of CIPN reflect an interaction between the toxic actions of the therapeutic and unique properties of the neurons deleteriously impacted." @default.
• W258154277 created "2016-06-24" @default.
• W258154277 creator A5009507330 @default.
• W258154277 creator A5076602561 @default.
• W258154277 date "2015-08-01" @default.
• W258154277 modified "2023-10-01" @default.
• W258154277 title "Sensory neuron subpopulation-specific dysregulation of intracellular calcium in a rat model of chemotherapy-induced peripheral neuropathy" @default.
• W258154277 cites W1248471033 @default.
• W258154277 cites W1526407692 @default.
• W258154277 cites W1599277155 @default.
• W258154277 cites W1623378741 @default.
• W258154277 cites W1964476129 @default.
• W258154277 cites W1968114963 @default.
• W258154277 cites W1971032720 @default.
• W258154277 cites W1974542461 @default.
• W258154277 cites W1980562969 @default.
• W258154277 cites W1980766932 @default.
• W258154277 cites W1981358093 @default.
• W258154277 cites W1986153984 @default.
• W258154277 cites W1986828765 @default.
• W258154277 cites W1987395974 @default.
• W258154277 cites W1988235122 @default.
• W258154277 cites W1989245704 @default.
• W258154277 cites W1991677710 @default.
• W258154277 cites W1993374392 @default.
• W258154277 cites W1995054952 @default.
• W258154277 cites W2002982652 @default.
• W258154277 cites W2003103971 @default.
• W258154277 cites W2015426350 @default.
• W258154277 cites W2019886473 @default.
• W258154277 cites W2025002129 @default.
• W258154277 cites W2027556819 @default.
• W258154277 cites W2027989691 @default.
• W258154277 cites W2032302528 @default.
• W258154277 cites W2039303620 @default.
• W258154277 cites W2039517962 @default.
• W258154277 cites W2042927086 @default.
• W258154277 cites W2043765720 @default.
• W258154277 cites W2049213018 @default.
• W258154277 cites W2056829170 @default.
• W258154277 cites W2059588106 @default.
• W258154277 cites W2061107749 @default.
• W258154277 cites W2071917333 @default.
• W258154277 cites W2082579490 @default.
• W258154277 cites W2083489519 @default.
• W258154277 cites W2084325495 @default.
• W258154277 cites W2084840118 @default.
• W258154277 cites W2091396511 @default.
• W258154277 cites W2096301608 @default.
• W258154277 cites W2107040951 @default.
• W258154277 cites W2112201877 @default.
• W258154277 cites W2128739179 @default.
• W258154277 cites W2130681302 @default.
• W258154277 cites W2131712556 @default.
• W258154277 cites W2159027399 @default.
• W258154277 cites W2159477730 @default.
• W258154277 cites W2168500751 @default.
• W258154277 cites W2184694295 @default.
• W258154277 cites W56542128 @default.
• W258154277 doi "https://doi.org/10.1016/j.neuroscience.2015.05.019" @default.
• W258154277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4485584" @default.
• W258154277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25982563" @default.
• W258154277 hasPublicationYear "2015" @default.
• W258154277 type Work @default.
• W258154277 sameAs 258154277 @default.
• W258154277 citedByCount "16" @default.
• W258154277 countsByYear W2581542772016 @default.
• W258154277 countsByYear W2581542772017 @default.
• W258154277 countsByYear W2581542772018 @default.
• W258154277 countsByYear W2581542772019 @default.
• W258154277 countsByYear W2581542772020 @default.
• W258154277 countsByYear W2581542772022 @default.
• W258154277 countsByYear W2581542772023 @default.
• W258154277 crossrefType "journal-article" @default.
• W258154277 hasAuthorship W258154277A5009507330 @default.
• W258154277 hasAuthorship W258154277A5076602561 @default.
• W258154277 hasBestOaLocation W2581542772 @default.
• W258154277 hasConcept C126322002 @default.
• W258154277 hasConcept C15490471 @default.
• W258154277 hasConcept C169760540 @default.
• W258154277 hasConcept C170493617 @default.
• W258154277 hasConcept C172659308 @default.
• W258154277 hasConcept C185263204 @default.
• W258154277 hasConcept C185592680 @default.
• W258154277 hasConcept C2775908076 @default.
• W258154277 hasConcept C2778794669 @default.
• W258154277 hasConcept C2780051329 @default.
• W258154277 hasConcept C4141045 @default.
• W258154277 hasConcept C46762472 @default.
• W258154277 hasConcept C71924100 @default.
• W258154277 hasConcept C86803240 @default.
• W258154277 hasConcept C94487597 @default.
• W258154277 hasConceptScore W258154277C126322002 @default.
• W258154277 hasConceptScore W258154277C15490471 @default.
• W258154277 hasConceptScore W258154277C169760540 @default.
• W258154277 hasConceptScore W258154277C170493617 @default.
• W258154277 hasConceptScore W258154277C172659308 @default.
• W258154277 hasConceptScore W258154277C185263204 @default.

• next