Matches in SemOpenAlex for { <https://semopenalex.org/work/W2581624985> ?p ?o ?g. }
- W2581624985 endingPage "208" @default.
- W2581624985 startingPage "208" @default.
- W2581624985 abstract "This extensive review covers research published between 2010 and 2012 regarding new compounds derived from marine sponges, including 62 species from 60 genera belonging to 33 families and 13 orders of the Demospongia class (Porifera). The emphasis is on the cytotoxic activity that bioactive metabolites from sponges may have on cancer cell lines. At least 197 novel chemical structures from 337 compounds isolated have been found to support this work. Details on the source and taxonomy of the sponges, their geographical occurrence, and a range of chemical structures are presented. The compounds discovered from the reviewed marine sponges fall into mainly four chemical classes: terpenoids (41.9%), alkaloids (26.2%), macrolides (8.9%) and peptides (6.3%) which, along with polyketides, sterols, and others show a range of biological activities. The key sponge orders studied in the reviewed research were Dictyoceratida, Haplosclerida, Tetractinellida, Poecilosclerida, and Agelasida. Petrosia, Haliclona (Haplosclerida), Rhabdastrella (Tetractinellida), Coscinoderma and Hyppospongia (Dictyioceratida), were found to be the most promising genera because of their capacity for producing new bioactive compounds. Several of the new compounds and their synthetic analogues have shown in vitro cytotoxic and pro-apoptotic activities against various tumor/cancer cell lines, and some of them will undergo further in vivo evaluation." @default.
- W2581624985 created "2017-02-03" @default.
- W2581624985 creator A5011843674 @default.
- W2581624985 creator A5033807244 @default.
- W2581624985 creator A5059879544 @default.
- W2581624985 creator A5066497311 @default.
- W2581624985 creator A5082825485 @default.
- W2581624985 creator A5087964985 @default.
- W2581624985 date "2017-01-28" @default.
- W2581624985 modified "2023-09-26" @default.
- W2581624985 title "Cytotoxic Compounds Derived from Marine Sponges. A Review (2010–2012)" @default.
- W2581624985 cites W1450867862 @default.
- W2581624985 cites W1553908537 @default.
- W2581624985 cites W1582566548 @default.
- W2581624985 cites W168242038 @default.
- W2581624985 cites W1965212047 @default.
- W2581624985 cites W1967088800 @default.
- W2581624985 cites W1968721621 @default.
- W2581624985 cites W1969072226 @default.
- W2581624985 cites W1971474224 @default.
- W2581624985 cites W1971798970 @default.
- W2581624985 cites W1978440247 @default.
- W2581624985 cites W1978656824 @default.
- W2581624985 cites W1984692285 @default.
- W2581624985 cites W1985183721 @default.
- W2581624985 cites W1985436520 @default.
- W2581624985 cites W1988904945 @default.
- W2581624985 cites W1989122924 @default.
- W2581624985 cites W1989704328 @default.
- W2581624985 cites W1992832880 @default.
- W2581624985 cites W1993289104 @default.
- W2581624985 cites W1994712754 @default.
- W2581624985 cites W1996154754 @default.
- W2581624985 cites W2000487721 @default.
- W2581624985 cites W2002084594 @default.
- W2581624985 cites W2005750825 @default.
- W2581624985 cites W2005757602 @default.
- W2581624985 cites W2005868853 @default.
- W2581624985 cites W2006948995 @default.
- W2581624985 cites W2008684332 @default.
- W2581624985 cites W2009270913 @default.
- W2581624985 cites W2016786844 @default.
- W2581624985 cites W2017041240 @default.
- W2581624985 cites W2018375706 @default.
- W2581624985 cites W2023091808 @default.
- W2581624985 cites W2026026036 @default.
- W2581624985 cites W2026063507 @default.
- W2581624985 cites W2026143290 @default.
- W2581624985 cites W2026967542 @default.
- W2581624985 cites W2029233926 @default.
- W2581624985 cites W2030969642 @default.
- W2581624985 cites W2031737517 @default.
- W2581624985 cites W2032889069 @default.
- W2581624985 cites W2033400700 @default.
- W2581624985 cites W2034544129 @default.
- W2581624985 cites W2036619542 @default.
- W2581624985 cites W2038285178 @default.
- W2581624985 cites W2039386186 @default.
- W2581624985 cites W2042259078 @default.
- W2581624985 cites W2043376079 @default.
- W2581624985 cites W2043651762 @default.
- W2581624985 cites W2044852418 @default.
- W2581624985 cites W2045170965 @default.
- W2581624985 cites W2048675682 @default.
- W2581624985 cites W2051665230 @default.
- W2581624985 cites W2051793395 @default.
- W2581624985 cites W2052129076 @default.
- W2581624985 cites W2053194782 @default.
- W2581624985 cites W2053438516 @default.
- W2581624985 cites W2056835863 @default.
- W2581624985 cites W2057312326 @default.
- W2581624985 cites W2058373730 @default.
- W2581624985 cites W2059551401 @default.
- W2581624985 cites W2060479908 @default.
- W2581624985 cites W2061411770 @default.
- W2581624985 cites W2061497601 @default.
- W2581624985 cites W2061944654 @default.
- W2581624985 cites W2068518369 @default.
- W2581624985 cites W2068532325 @default.
- W2581624985 cites W2072830243 @default.
- W2581624985 cites W2074890788 @default.
- W2581624985 cites W2075188309 @default.
- W2581624985 cites W2075861097 @default.
- W2581624985 cites W2076692590 @default.
- W2581624985 cites W2078901029 @default.
- W2581624985 cites W2081194765 @default.
- W2581624985 cites W2082264875 @default.
- W2581624985 cites W2087200853 @default.
- W2581624985 cites W2087441633 @default.
- W2581624985 cites W2087563815 @default.
- W2581624985 cites W2087928681 @default.
- W2581624985 cites W2089286791 @default.
- W2581624985 cites W2090014580 @default.
- W2581624985 cites W2090983550 @default.
- W2581624985 cites W2094275930 @default.
- W2581624985 cites W2096361076 @default.
- W2581624985 cites W2100475490 @default.
- W2581624985 cites W2107288803 @default.