FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2581696898> ?p ?o ?g. }

• W2581696898 abstract "Abstract Mismatch repair (MMR) is a near ubiquitous pathway, essential for the maintenance of genome stability. Members of the MutS and MutL protein families perform key steps in mismatch correction. Despite the major importance of this repair pathway, MutS–MutL are absent in almost all Actinobacteria and many Archaea. However, these organisms exhibit rates and spectra of spontaneous mutations similar to MMR-bearing species, suggesting the existence of an alternative to the canonical MutS–MutL-based MMR. Here we report that Mycobacterium smegmatis NucS/EndoMS, a putative endonuclease with no structural homology to known MMR factors, is required for mutation avoidance and anti-recombination, hallmarks of the canonical MMR. Furthermore, phenotypic analysis of naturally occurring polymorphic NucS in a M. smegmatis surrogate model, suggests the existence of M. tuberculosis mutator strains. The phylogenetic analysis of NucS indicates a complex evolutionary process leading to a disperse distribution pattern in prokaryotes. Together, these findings indicate that distinct pathways for MMR have evolved at least twice in nature." @default.
• W2581696898 created "2017-02-03" @default.
• W2581696898 creator A5006005815 @default.
• W2581696898 creator A5009998363 @default.
• W2581696898 creator A5014807192 @default.
• W2581696898 creator A5015719067 @default.
• W2581696898 creator A5018816755 @default.
• W2581696898 creator A5030694212 @default.
• W2581696898 creator A5045822931 @default.
• W2581696898 creator A5050333044 @default.
• W2581696898 creator A5055888908 @default.
• W2581696898 creator A5057327308 @default.
• W2581696898 creator A5058878749 @default.
• W2581696898 creator A5063141051 @default.
• W2581696898 creator A5063786281 @default.
• W2581696898 creator A5067929752 @default.
• W2581696898 creator A5083283501 @default.
• W2581696898 creator A5086535550 @default.
• W2581696898 creator A5088267405 @default.
• W2581696898 date "2017-01-27" @default.
• W2581696898 modified "2023-10-14" @default.
• W2581696898 title "A non-canonical mismatch repair pathway in prokaryotes" @default.
• W2581696898 cites W1490937614 @default.
• W2581696898 cites W1496346569 @default.
• W2581696898 cites W1657643071 @default.
• W2581696898 cites W1929328533 @default.
• W2581696898 cites W1972014674 @default.
• W2581696898 cites W1972490342 @default.
• W2581696898 cites W1979172052 @default.
• W2581696898 cites W1985687704 @default.
• W2581696898 cites W2006614927 @default.
• W2581696898 cites W2009203187 @default.
• W2581696898 cites W2011226772 @default.
• W2581696898 cites W2019385975 @default.
• W2581696898 cites W2029780301 @default.
• W2581696898 cites W2036463521 @default.
• W2581696898 cites W2043532115 @default.
• W2581696898 cites W2052519733 @default.
• W2581696898 cites W2054621069 @default.
• W2581696898 cites W2065505308 @default.
• W2581696898 cites W2071310636 @default.
• W2581696898 cites W2072244058 @default.
• W2581696898 cites W2078290231 @default.
• W2581696898 cites W2078968949 @default.
• W2581696898 cites W2092403679 @default.
• W2581696898 cites W2093975175 @default.
• W2581696898 cites W2094461142 @default.
• W2581696898 cites W2101994201 @default.
• W2581696898 cites W2105341822 @default.
• W2581696898 cites W2106265368 @default.
• W2581696898 cites W2112331024 @default.
• W2581696898 cites W2126490800 @default.
• W2581696898 cites W2127774996 @default.
• W2581696898 cites W2135185499 @default.
• W2581696898 cites W2137597742 @default.
• W2581696898 cites W2139086659 @default.
• W2581696898 cites W2142618175 @default.
• W2581696898 cites W2146192260 @default.
• W2581696898 cites W2150600032 @default.
• W2581696898 cites W2151031722 @default.
• W2581696898 cites W2153303237 @default.
• W2581696898 cites W2156057042 @default.
• W2581696898 cites W2163627198 @default.
• W2581696898 cites W2168696662 @default.
• W2581696898 cites W2169053394 @default.
• W2581696898 cites W2185950865 @default.
• W2581696898 cites W2315521535 @default.
• W2581696898 cites W2326157936 @default.
• W2581696898 cites W2336330109 @default.
• W2581696898 cites W2398070776 @default.
• W2581696898 cites W2533162091 @default.
• W2581696898 cites W3145289798 @default.
• W2581696898 doi "https://doi.org/10.1038/ncomms14246" @default.
• W2581696898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5290159" @default.
• W2581696898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28128207" @default.
• W2581696898 hasPublicationYear "2017" @default.
• W2581696898 type Work @default.
• W2581696898 sameAs 2581696898 @default.
• W2581696898 citedByCount "71" @default.
• W2581696898 countsByYear W25816968982017 @default.
• W2581696898 countsByYear W25816968982018 @default.
• W2581696898 countsByYear W25816968982019 @default.
• W2581696898 countsByYear W25816968982020 @default.
• W2581696898 countsByYear W25816968982021 @default.
• W2581696898 countsByYear W25816968982022 @default.
• W2581696898 countsByYear W25816968982023 @default.
• W2581696898 crossrefType "journal-article" @default.
• W2581696898 hasAuthorship W2581696898A5006005815 @default.
• W2581696898 hasAuthorship W2581696898A5009998363 @default.
• W2581696898 hasAuthorship W2581696898A5014807192 @default.
• W2581696898 hasAuthorship W2581696898A5015719067 @default.
• W2581696898 hasAuthorship W2581696898A5018816755 @default.
• W2581696898 hasAuthorship W2581696898A5030694212 @default.
• W2581696898 hasAuthorship W2581696898A5045822931 @default.
• W2581696898 hasAuthorship W2581696898A5050333044 @default.
• W2581696898 hasAuthorship W2581696898A5055888908 @default.
• W2581696898 hasAuthorship W2581696898A5057327308 @default.
• W2581696898 hasAuthorship W2581696898A5058878749 @default.
• W2581696898 hasAuthorship W2581696898A5063141051 @default.
• W2581696898 hasAuthorship W2581696898A5063786281 @default.

• next