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- W2581715987 abstract "Reproductive technologies associated with the development of sensitive molecular methods at the single-cell level, have allowed the preimplantation genetic diagnosis (PGD) in human embryos before uterine implantation. The procedure, which entails the removal of one or two blastomere from day 3 embryos, decrease the possibility of trisomic chromosome offspring, reduce the chances of spontaneous abortions, and increase the chances of pregnancy by transferring embryos numerically normal for the evaluated chromosomes. Patients subjected to PGD, usually, were treated through ICSI, the normal practice to avoid possible sperm DNA contamination. In this study we have compare results gotten after ICSI-PGD and IVF-PGD. Case controlled study Written informed consent was obtained in all cases. The study population consisted in 42 patients. Patients underwent to PGD due to advanced maternal age; familial genetic diseases; abnormal karyotype; recurrent miscarriage and severe male infertility. Of those, 23 patients (54.8%) underwent to ICSI-PGD and 19 (45.2%) who not accepted ICSI procedure due to religious concepts, underwent to IVF previously PGD. Embryo biopsy and blastomere fixation was performed 72 hours after injection. For the multicolor fluorescent in situ hybridization (FISH) analysis, five DNA probes were used for the simultaneous detection of chromosomes X, Y, 13, 18 and 21. FISH normal embryos were transferred in the afternoon of the same day of biopsy or in the morning, in day after. A total of 185 morphological normal day 3 embryos were analyzed. In 6 ICSI-PGD (26.1%) and in 3 IVF-PGD (15.8%) cycles, there were no embryos available to be transferred (p=0.476). Complementary results are shown in table I.Tabled 1 In spite of higher maternal age in patients from IVF-PGD group, there was no statistical difference between the results when ICSI or IVF-PGD results were compared. In some situations due to cultural background, religious authority and the law, PGD can be done after IVF procedure without damage in results." @default.
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- W2581715987 date "2006-09-01" @default.
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- W2581715987 title "P-940" @default.
- W2581715987 doi "https://doi.org/10.1016/j.fertnstert.2006.07.1333" @default.
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