FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2581716463> ?p ?o ?g. }

• W2581716463 endingPage "1345" @default.
• W2581716463 startingPage "1334" @default.
• W2581716463 abstract "Type 1 diabetes is characterized by the loss of insulin production caused by β-cell dysfunction and/or destruction. The hypothesis that β-cell loss occurs early during the prediabetic phase has recently been challenged. Here we show, for the first time in situ, that in pancreas sections from autoantibody-positive (Ab+) donors, insulin area and β-cell mass are maintained before disease onset and that production of proinsulin increases. This suggests that β-cell destruction occurs more precipitously than previously assumed. Indeed, the pancreatic proinsulin-to-insulin area ratio was also increased in these donors with prediabetes. Using high-resolution confocal microscopy, we found a high accumulation of vesicles containing proinsulin in β-cells from Ab+ donors, suggesting a defect in proinsulin conversion or an accumulation of immature vesicles caused by an increase in insulin demand and/or a dysfunction in vesicular trafficking. In addition, islets from Ab+ donors were larger and contained a higher number of β-cells per islet. Our data indicate that β-cell mass (and function) is maintained until shortly before diagnosis and declines rapidly at the time of clinical onset of disease. This suggests that secondary prevention before onset, when β-cell mass is still intact, could be a successful therapeutic strategy." @default.
• W2581716463 created "2017-02-03" @default.
• W2581716463 creator A5005235926 @default.
• W2581716463 creator A5006823994 @default.
• W2581716463 creator A5015949107 @default.
• W2581716463 creator A5049823714 @default.
• W2581716463 creator A5055573840 @default.
• W2581716463 creator A5061334836 @default.
• W2581716463 creator A5089948249 @default.
• W2581716463 creator A5090718680 @default.
• W2581716463 date "2017-01-30" @default.
• W2581716463 modified "2023-10-17" @default.
• W2581716463 title "Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset" @default.
• W2581716463 cites W1461005234 @default.
• W2581716463 cites W1863320924 @default.
• W2581716463 cites W1913359344 @default.
• W2581716463 cites W1915692069 @default.
• W2581716463 cites W1981710185 @default.
• W2581716463 cites W1986710313 @default.
• W2581716463 cites W2005132190 @default.
• W2581716463 cites W2025682280 @default.
• W2581716463 cites W2026513127 @default.
• W2581716463 cites W2044481899 @default.
• W2581716463 cites W2053998815 @default.
• W2581716463 cites W2056129497 @default.
• W2581716463 cites W2066824357 @default.
• W2581716463 cites W2083968123 @default.
• W2581716463 cites W2084009063 @default.
• W2581716463 cites W2084707443 @default.
• W2581716463 cites W2088945279 @default.
• W2581716463 cites W2090312623 @default.
• W2581716463 cites W2095256598 @default.
• W2581716463 cites W2109532285 @default.
• W2581716463 cites W2112530229 @default.
• W2581716463 cites W2114536452 @default.
• W2581716463 cites W2116577997 @default.
• W2581716463 cites W2119249252 @default.
• W2581716463 cites W2120816431 @default.
• W2581716463 cites W2122756500 @default.
• W2581716463 cites W2126981851 @default.
• W2581716463 cites W2129387684 @default.
• W2581716463 cites W2130601108 @default.
• W2581716463 cites W2152808521 @default.
• W2581716463 cites W2161945989 @default.
• W2581716463 cites W2163917240 @default.
• W2581716463 cites W2166775500 @default.
• W2581716463 cites W2175468670 @default.
• W2581716463 cites W2192080449 @default.
• W2581716463 cites W2297529967 @default.
• W2581716463 cites W2324068091 @default.
• W2581716463 cites W2324838759 @default.
• W2581716463 cites W2326904657 @default.
• W2581716463 cites W2421023472 @default.
• W2581716463 cites W2467561455 @default.
• W2581716463 cites W2469378597 @default.
• W2581716463 cites W2502567773 @default.
• W2581716463 cites W2541443144 @default.
• W2581716463 cites W2555906390 @default.
• W2581716463 cites W2560165191 @default.
• W2581716463 doi "https://doi.org/10.2337/db16-1343" @default.
• W2581716463 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5399615" @default.
• W2581716463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28137793" @default.
• W2581716463 hasPublicationYear "2017" @default.
• W2581716463 type Work @default.
• W2581716463 sameAs 2581716463 @default.
• W2581716463 citedByCount "78" @default.
• W2581716463 countsByYear W25817164632017 @default.
• W2581716463 countsByYear W25817164632018 @default.
• W2581716463 countsByYear W25817164632019 @default.
• W2581716463 countsByYear W25817164632020 @default.
• W2581716463 countsByYear W25817164632021 @default.
• W2581716463 countsByYear W25817164632022 @default.
• W2581716463 countsByYear W25817164632023 @default.
• W2581716463 crossrefType "journal-article" @default.
• W2581716463 hasAuthorship W2581716463A5005235926 @default.
• W2581716463 hasAuthorship W2581716463A5006823994 @default.
• W2581716463 hasAuthorship W2581716463A5015949107 @default.
• W2581716463 hasAuthorship W2581716463A5049823714 @default.
• W2581716463 hasAuthorship W2581716463A5055573840 @default.
• W2581716463 hasAuthorship W2581716463A5061334836 @default.
• W2581716463 hasAuthorship W2581716463A5089948249 @default.
• W2581716463 hasAuthorship W2581716463A5090718680 @default.
• W2581716463 hasBestOaLocation W25817164631 @default.
• W2581716463 hasConcept C126322002 @default.
• W2581716463 hasConcept C134018914 @default.
• W2581716463 hasConcept C1491633281 @default.
• W2581716463 hasConcept C159654299 @default.
• W2581716463 hasConcept C163764329 @default.
• W2581716463 hasConcept C165220095 @default.
• W2581716463 hasConcept C203014093 @default.
• W2581716463 hasConcept C2777180221 @default.
• W2581716463 hasConcept C2778764654 @default.
• W2581716463 hasConcept C2779306644 @default.
• W2581716463 hasConcept C2779668308 @default.
• W2581716463 hasConcept C2781232474 @default.
• W2581716463 hasConcept C55493867 @default.
• W2581716463 hasConcept C555293320 @default.
• W2581716463 hasConcept C71924100 @default.

• next