Matches in SemOpenAlex for { <https://semopenalex.org/work/W2581720089> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2581720089 endingPage "427" @default.
- W2581720089 startingPage "424" @default.
- W2581720089 abstract "Continuation despite the progression seems at first glance justified in the case of targeted drugs aimed at molecular pathways on which the tumour is dependent (oncogene addiction). Glivec and chronic myeloid leukemia and GIST is an illustration of this phenomenon, but in the case of common solid tumours such as lung cancer, pancreatic cancer, breast cancer, molecular heterogeneity of the tumour cell subpopulations makes further treatment after progression risky. It may actually not inhibit, but accelerate the disease. Clinical proof of this are recently presented results of the IMPRESS study in NSCLC, where continued treatment with kinase inhibitor and chemotherapy after progression caused shortened overall survival, Experimental explanation of this phenomenon makes relevant the work involving vemurafenib and melanoma in the mouse model, in which continued treatment leads to accelerated progression and, on the contrary, a pause in treatment (drug holiday) caused inhibition of tumour growth. The use of continued treatment after progression in colon cancer with bevacizumab was associated with extended time to progression (the effect is statistically significant but clinically minimal), which forces us to reflect on clinical trials, in which a small clinical benefit is obtained but engages thousands of patients." @default.
- W2581720089 created "2017-02-03" @default.
- W2581720089 creator A5071040712 @default.
- W2581720089 date "2016-01-08" @default.
- W2581720089 modified "2023-10-18" @default.
- W2581720089 title "Zasadność kontynuacji leczenia celowanego po progresji jest wątpliwa" @default.
- W2581720089 doi "https://doi.org/10.5603/njo.2015.0082" @default.
- W2581720089 hasPublicationYear "2016" @default.
- W2581720089 type Work @default.
- W2581720089 sameAs 2581720089 @default.
- W2581720089 citedByCount "0" @default.
- W2581720089 crossrefType "journal-article" @default.
- W2581720089 hasAuthorship W2581720089A5071040712 @default.
- W2581720089 hasBestOaLocation W25817200891 @default.
- W2581720089 hasConcept C121608353 @default.
- W2581720089 hasConcept C126322002 @default.
- W2581720089 hasConcept C143998085 @default.
- W2581720089 hasConcept C2776131300 @default.
- W2581720089 hasConcept C2776694085 @default.
- W2581720089 hasConcept C2777658100 @default.
- W2581720089 hasConcept C2777802072 @default.
- W2581720089 hasConcept C2779134260 @default.
- W2581720089 hasConcept C2780210213 @default.
- W2581720089 hasConcept C2994587330 @default.
- W2581720089 hasConcept C502942594 @default.
- W2581720089 hasConcept C535046627 @default.
- W2581720089 hasConcept C71924100 @default.
- W2581720089 hasConceptScore W2581720089C121608353 @default.
- W2581720089 hasConceptScore W2581720089C126322002 @default.
- W2581720089 hasConceptScore W2581720089C143998085 @default.
- W2581720089 hasConceptScore W2581720089C2776131300 @default.
- W2581720089 hasConceptScore W2581720089C2776694085 @default.
- W2581720089 hasConceptScore W2581720089C2777658100 @default.
- W2581720089 hasConceptScore W2581720089C2777802072 @default.
- W2581720089 hasConceptScore W2581720089C2779134260 @default.
- W2581720089 hasConceptScore W2581720089C2780210213 @default.
- W2581720089 hasConceptScore W2581720089C2994587330 @default.
- W2581720089 hasConceptScore W2581720089C502942594 @default.
- W2581720089 hasConceptScore W2581720089C535046627 @default.
- W2581720089 hasConceptScore W2581720089C71924100 @default.
- W2581720089 hasIssue "5" @default.
- W2581720089 hasLocation W25817200891 @default.
- W2581720089 hasOpenAccess W2581720089 @default.
- W2581720089 hasPrimaryLocation W25817200891 @default.
- W2581720089 hasRelatedWork W1921841920 @default.
- W2581720089 hasRelatedWork W2328771497 @default.
- W2581720089 hasRelatedWork W2476446980 @default.
- W2581720089 hasRelatedWork W2490311954 @default.
- W2581720089 hasRelatedWork W2619622310 @default.
- W2581720089 hasRelatedWork W2790628335 @default.
- W2581720089 hasRelatedWork W2790945713 @default.
- W2581720089 hasRelatedWork W2945942726 @default.
- W2581720089 hasRelatedWork W3045209127 @default.
- W2581720089 hasRelatedWork W4297856966 @default.
- W2581720089 hasVolume "65" @default.
- W2581720089 isParatext "false" @default.
- W2581720089 isRetracted "false" @default.
- W2581720089 magId "2581720089" @default.
- W2581720089 workType "article" @default.