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- W2581788240 abstract "Objectives: We have studied patients submitted to twelve core prostate biopsy (Bx12C) to evaluate its sensitivity in the diagnosis of prostate cancer (PCa) as well as the addition of pathologic information when compared to those obtained by sextant prostate biopsy (Bx6C) guided by transrectal ultrasound. Materials and Methods: Seventy-eight men underwent Bx12C. Transrectal ultrasound evaluated prostate volume and guided the biopsies to the 12 following areas: right and left apex, right and left mid prostate, right and left base, right and left transition zone, 1 and 2 right mid-lateral and 1 and 2 left mid-lateral. The efficiency of the Bx12C was compared to the 6 cores of the Bx6C in the same patients. Results: Mean PSA was 17.3 ng/ml and 60 patients (77%) had abnormal digital rectal examination. The Bx12C diagnosed 28 prostate cancers (35%), adding 2 (8%) tumors (p = 0.81) and 2 (50%) cases of prostatic intraepithelial neoplasia (PIN) to the Bx6C. The Bx12C added 2 tumors to the 4 diagnosed by the Bx6C in the 6 patients with prostate cancer whose prostates weighed more than 40 grams. On the other hand, the Bx12C did not add any neoplasia (p = 0.039) in the 22 patients with prostate cancer whose prostates weighed less than 40 grams. In PCa cases, the additional cores increased the percentage of positive cores in 4 cases, diagnosed bilateral PCa in 1 case, increased Gleason’s score in 1 case and added 2 cases of perineural infiltration. Conclusions: The Bx12C does not increase prostate cancer detection when compared to the Bx6C among patients with high serum PSA and palpable nodule. In the patients subgroup with prostates > 40 g, Bx12C increased the number of PCa diagnosed." @default.
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- W2581788240 date "2002-01-01" @default.
- W2581788240 modified "2023-09-23" @default.
- W2581788240 title "TWELVE CORE PROSTATE BIOPSY VERSUS SIX SYSTEMATIC SEXTANT BIOPSIES" @default.
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