FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2581943747> ?p ?o ?g. }

• W2581943747 abstract "B10 Objectives: Gliomas are uniformly lethal with average survival following diagnosis of 12 to 18 months. Biological markers coupled with techniques in molecular imaging might aid to selectively visualize intracranial gliomas. This new feasibility is important in the diagnoses, treatment, and surveillance of these lethal tumors. NM404, a novel phospholipid ether analog currently in clinical Phase 1 trials for human lung cancer, demonstrates striking tumor avidity in 32 rodent models of human cancer. The primary aim of this study was to examine the multi-modal imaging characteristics of intracranial rat gliomas by comparing 124I-NM404 with microPET and microCT against the current gold standard of gadolinium enhanced microMRI. Secondary aims are to evaluate signal to background noise in tumor versus normal brain tissue, and corroborate imaging with histology. Our goal is to determine whether NM404 might be useful in the treatment of patients with gliomas. Methods: The frontal lobes of five Fischer rats weighing between 125-150g were inoculated with 1.5x106 RG2 rat glioma cells in 5ul of methylcellulose. Seven days after inoculation, 124I-NM404 was injected intravenously (80-100μCi/0.2ml) into rats bearing tumors with maximum diameters of 7-12mm. Serial PET scans were obtained at 6, 12, 24, 48, 96 hours and at 12 days. Signal intensity was assessed by comparing the tumor-bearing side to the opposite hemisphere in the same animal. All five rats displayed signs of neurological deterioration by 12 days after inoculation. Animals were scanned using PET, MRI with gadolinium and CT and then sacrificed. Brains were harvested, digitally photographed and sent for histological analysis including microglial studies in another laboratory. Results: 124I-NM404 with PET provided a more accurate image of the tumor than MRI with gadolinium indicating the new imaging modality is better than the current gold standard. Fused CT and PET images provided an accurate three-dimensional anatomical model. NM404 uptake corresponded to tumor location by histology. Tumor signal intensity was significantly higher than background and persisted for 12 days after inoculation. Uptake of NM404 tightly correlated with tumor location as determined by histology. Interestingly, the number of viable cells within a tumor appeared to decline, indicating radiolabeled NM404 might have a therapeutic effect. Conclusion: Preliminary results indicate NM404 displays an intense avidity to gliomas. 124I-NM404 might have utility in diagnoses, treatment and surveillance of gliomas. Further studies utilizing 125I and 124I with NM404 need to be completed in order to fully characterize the imaging and therapeutic potential prior to clinical application." @default.
• W2581943747 created "2017-02-03" @default.
• W2581943747 creator A5009625153 @default.
• W2581943747 creator A5013731126 @default.
• W2581943747 creator A5015007713 @default.
• W2581943747 creator A5020348391 @default.
• W2581943747 creator A5026680523 @default.
• W2581943747 date "2006-12-01" @default.
• W2581943747 modified "2023-09-23" @default.
• W2581943747 title "Evaluation of 124I-NM404 as a universal agent for the detection and surveillance of intracranial malignancies." @default.
• W2581943747 hasPublicationYear "2006" @default.
• W2581943747 type Work @default.
• W2581943747 sameAs 2581943747 @default.
• W2581943747 citedByCount "0" @default.
• W2581943747 crossrefType "journal-article" @default.
• W2581943747 hasAuthorship W2581943747A5009625153 @default.
• W2581943747 hasAuthorship W2581943747A5013731126 @default.
• W2581943747 hasAuthorship W2581943747A5015007713 @default.
• W2581943747 hasAuthorship W2581943747A5020348391 @default.
• W2581943747 hasAuthorship W2581943747A5026680523 @default.
• W2581943747 hasConcept C126838900 @default.
• W2581943747 hasConcept C142724271 @default.
• W2581943747 hasConcept C159654299 @default.
• W2581943747 hasConcept C179223381 @default.
• W2581943747 hasConcept C203014093 @default.
• W2581943747 hasConcept C2778227246 @default.
• W2581943747 hasConcept C2779130545 @default.
• W2581943747 hasConcept C2989005 @default.
• W2581943747 hasConcept C502942594 @default.
• W2581943747 hasConcept C71924100 @default.
• W2581943747 hasConceptScore W2581943747C126838900 @default.
• W2581943747 hasConceptScore W2581943747C142724271 @default.
• W2581943747 hasConceptScore W2581943747C159654299 @default.
• W2581943747 hasConceptScore W2581943747C179223381 @default.
• W2581943747 hasConceptScore W2581943747C203014093 @default.
• W2581943747 hasConceptScore W2581943747C2778227246 @default.
• W2581943747 hasConceptScore W2581943747C2779130545 @default.
• W2581943747 hasConceptScore W2581943747C2989005 @default.
• W2581943747 hasConceptScore W2581943747C502942594 @default.
• W2581943747 hasConceptScore W2581943747C71924100 @default.
• W2581943747 hasLocation W25819437471 @default.
• W2581943747 hasOpenAccess W2581943747 @default.
• W2581943747 hasPrimaryLocation W25819437471 @default.
• W2581943747 hasRelatedWork W1972589614 @default.
• W2581943747 hasRelatedWork W1977780486 @default.
• W2581943747 hasRelatedWork W2008182592 @default.
• W2581943747 hasRelatedWork W2025970917 @default.
• W2581943747 hasRelatedWork W2043743705 @default.
• W2581943747 hasRelatedWork W2049495203 @default.
• W2581943747 hasRelatedWork W2124804502 @default.
• W2581943747 hasRelatedWork W2313150044 @default.
• W2581943747 hasRelatedWork W2354966207 @default.
• W2581943747 hasRelatedWork W2363778441 @default.
• W2581943747 hasRelatedWork W2367948779 @default.
• W2581943747 hasRelatedWork W2378435998 @default.
• W2581943747 hasRelatedWork W2490888851 @default.
• W2581943747 hasRelatedWork W2586186137 @default.
• W2581943747 hasRelatedWork W2771033857 @default.
• W2581943747 hasRelatedWork W280118943 @default.
• W2581943747 hasRelatedWork W2806588896 @default.
• W2581943747 hasRelatedWork W2886020660 @default.
• W2581943747 hasRelatedWork W1832604249 @default.
• W2581943747 hasRelatedWork W2298188352 @default.
• W2581943747 hasVolume "15" @default.
• W2581943747 isParatext "false" @default.
• W2581943747 isRetracted "false" @default.
• W2581943747 magId "2581943747" @default.
• W2581943747 workType "article" @default.