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• W2582020140 abstract "Deregulation of the canonical Wnt signaling pathway plays an important role in human tumorigenesis through the accumulation of β‐catenin and subsequent transactivation of TCF 7L2. Although some of the consequences associated with the accumulated β‐catenin have been clarified, the comprehensive effect of activated β‐catenin/ TCF 7L2 transcriptional complex on tumorigenesis remains to be elucidated. To understand the precise molecular mechanisms underlying colorectal cancer, we searched for genes regulated by the complex in colorectal tumors. We performed expression profile analysis of HCT 116 and SW 480 colon cancer cells treated with β‐catenin si RNA s, and Ch IP ‐sequencing using anti‐ TCF 7L2 antibody. Combination of these data with public microarray data of LS 174 cells with a dominant‐negative form of TCF 7L2 identified a total of 11 candidate genes. In this paper, we focused on FERM domain‐containing protein 5 ( FRMD 5), and confirmed that it is regulated by both β‐catenin and TCF 7L2. An additional reporter assay disclosed that a region in intron1 transcriptionally regulated the expression of FRMD 5 . Ch IP assay also corroborated that TCF 7L2 associates with this region. These data suggested that FRMD 5 is a novel direct target of the β‐catenin/ TCF 7L2 complex." @default.
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• W2582020140 date "2017-04-01" @default.
• W2582020140 modified "2023-10-04" @default.
• W2582020140 title "Identification of FERM domain-containing protein 5 as a novel target of β-catenin/TCF7L2 complex" @default.
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• W2582020140 doi "https://doi.org/10.1111/cas.13174" @default.
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