FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2582063395> ?p ?o ?g. }

• W2582063395 endingPage "1421" @default.
• W2582063395 startingPage "1411" @default.
• W2582063395 abstract "Based on our previous data on the presence of very small superparamagnetic iron oxide nanoparticles (VSOP) on brain endothelial structures during experimental autoimmune encephalomyelitis (EAE), we investigated the mechanisms of VSOP binding on inflamed brain endothelial cells in vivo and in vitro. After intravenous application, VSOP were detected in brain endothelial cells of EAE animals at peak disease and prior to clinical onset. In vitro, inflammatory stimuli increased VSOP uptake by brain endothelial bEnd.3 cells, which we confirmed in primary endothelial cells and in bEnd.3 cells cultured under shear stress. Transmission electron microscopy and blocking experiments revealed that during inflammation VSOP were endocytosed by bEnd.3. Modified sulfated glycosaminoglycans (GAG) on inflamed brain endothelial cells were the primary binding site for VSOP, as GAG degradation and inhibition of GAG sulfation reduced VSOP uptake. Thus, VSOP-based MRI is sensitive to visualize early neuroinflammatory processes such as GAG modifications on brain endothelial cells." @default.
• W2582063395 created "2017-02-03" @default.
• W2582063395 creator A5000754720 @default.
• W2582063395 creator A5009885344 @default.
• W2582063395 creator A5012711590 @default.
• W2582063395 creator A5019201720 @default.
• W2582063395 creator A5021574965 @default.
• W2582063395 creator A5049736067 @default.
• W2582063395 creator A5049769160 @default.
• W2582063395 creator A5052945233 @default.
• W2582063395 creator A5056912783 @default.
• W2582063395 creator A5066024951 @default.
• W2582063395 creator A5066508060 @default.
• W2582063395 date "2017-05-01" @default.
• W2582063395 modified "2023-10-03" @default.
• W2582063395 title "Inflammation-induced brain endothelial activation leads to uptake of electrostatically stabilized iron oxide nanoparticles via sulfated glycosaminoglycans" @default.
• W2582063395 cites W1505042932 @default.
• W2582063395 cites W1567868451 @default.
• W2582063395 cites W1771281055 @default.
• W2582063395 cites W1868047048 @default.
• W2582063395 cites W1964544761 @default.
• W2582063395 cites W1966542373 @default.
• W2582063395 cites W1968493141 @default.
• W2582063395 cites W1968873490 @default.
• W2582063395 cites W1970336973 @default.
• W2582063395 cites W1977538857 @default.
• W2582063395 cites W1980990502 @default.
• W2582063395 cites W1989096983 @default.
• W2582063395 cites W1997140154 @default.
• W2582063395 cites W2001267675 @default.
• W2582063395 cites W2006524259 @default.
• W2582063395 cites W2013090236 @default.
• W2582063395 cites W2017201573 @default.
• W2582063395 cites W2018709506 @default.
• W2582063395 cites W2019268848 @default.
• W2582063395 cites W2022603662 @default.
• W2582063395 cites W2028502203 @default.
• W2582063395 cites W2031354813 @default.
• W2582063395 cites W2032039569 @default.
• W2582063395 cites W2046748764 @default.
• W2582063395 cites W2060635700 @default.
• W2582063395 cites W2067394007 @default.
• W2582063395 cites W2067810471 @default.
• W2582063395 cites W2067822704 @default.
• W2582063395 cites W2069748232 @default.
• W2582063395 cites W2084916305 @default.
• W2582063395 cites W2090419287 @default.
• W2582063395 cites W2102862146 @default.
• W2582063395 cites W2113452176 @default.
• W2582063395 cites W2117696215 @default.
• W2582063395 cites W2122718589 @default.
• W2582063395 cites W2135346209 @default.
• W2582063395 cites W2164268814 @default.
• W2582063395 cites W2174649710 @default.
• W2582063395 cites W2290716667 @default.
• W2582063395 cites W2318269276 @default.
• W2582063395 cites W2323543821 @default.
• W2582063395 cites W2331963576 @default.
• W2582063395 cites W2417748216 @default.
• W2582063395 cites W2479797790 @default.
• W2582063395 cites W2520662515 @default.
• W2582063395 doi "https://doi.org/10.1016/j.nano.2017.01.010" @default.
• W2582063395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28131884" @default.
• W2582063395 hasPublicationYear "2017" @default.
• W2582063395 type Work @default.
• W2582063395 sameAs 2582063395 @default.
• W2582063395 citedByCount "19" @default.
• W2582063395 countsByYear W25820633952017 @default.
• W2582063395 countsByYear W25820633952018 @default.
• W2582063395 countsByYear W25820633952019 @default.
• W2582063395 countsByYear W25820633952020 @default.
• W2582063395 countsByYear W25820633952021 @default.
• W2582063395 countsByYear W25820633952022 @default.
• W2582063395 countsByYear W25820633952023 @default.
• W2582063395 crossrefType "journal-article" @default.
• W2582063395 hasAuthorship W2582063395A5000754720 @default.
• W2582063395 hasAuthorship W2582063395A5009885344 @default.
• W2582063395 hasAuthorship W2582063395A5012711590 @default.
• W2582063395 hasAuthorship W2582063395A5019201720 @default.
• W2582063395 hasAuthorship W2582063395A5021574965 @default.
• W2582063395 hasAuthorship W2582063395A5049736067 @default.
• W2582063395 hasAuthorship W2582063395A5049769160 @default.
• W2582063395 hasAuthorship W2582063395A5052945233 @default.
• W2582063395 hasAuthorship W2582063395A5056912783 @default.
• W2582063395 hasAuthorship W2582063395A5066024951 @default.
• W2582063395 hasAuthorship W2582063395A5066508060 @default.
• W2582063395 hasBestOaLocation W25820633952 @default.
• W2582063395 hasConcept C123012128 @default.
• W2582063395 hasConcept C12554922 @default.
• W2582063395 hasConcept C150903083 @default.
• W2582063395 hasConcept C153074725 @default.
• W2582063395 hasConcept C155138218 @default.
• W2582063395 hasConcept C155672457 @default.
• W2582063395 hasConcept C169760540 @default.
• W2582063395 hasConcept C171250308 @default.
• W2582063395 hasConcept C185592680 @default.
• W2582063395 hasConcept C192562407 @default.
• W2582063395 hasConcept C202751555 @default.

• next