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- W2582088930 abstract "Bipolar disorder is a recurrent and highly incapacitating illness, related to inflammation and changes in the insulin-like growth factor 1 (IGF-1). The objective of this study was to evaluate serum levels of IGF-1 in bipolar disorder patients and its relation to inflammation. We included 31 patients with bipolar disorder and 33 healthy controls. Serum concentrations of IGF-1, growth hormone (GH), insulin and tumor necrosis factor α (TNF-α) were analyzed. The serum levels of IGF-1 seem to be increased in bipolar disorder patients (248.84±104.91 ng/mL) compared to controls (169.18±74.16 ng/mL). Comparing reference values of IGF serum concentrations between groups, we found that 32% of patients had increased IGF-1 serum concentrations while only 3% of subjects are above normal range. We did not find statistically significant differences between groups in the concentration of insulin, GH, and TNF-α. This study suggests an association between IGF-1 in the pathophysiology of bipolar disorder. It is possible that this peripheral increase is related to a central nervous system increased resistance to IGF-1, thus reducing its neuroprotective action." @default.
- W2582088930 created "2017-02-03" @default.
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- W2582088930 date "2017-04-01" @default.
- W2582088930 modified "2023-10-18" @default.
- W2582088930 title "Peripheral insulin-like growth factor 1 in bipolar disorder" @default.
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- W2582088930 doi "https://doi.org/10.1016/j.psychres.2017.01.061" @default.
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