Matches in SemOpenAlex for { <https://semopenalex.org/work/W2582128857> ?p ?o ?g. }
- W2582128857 abstract "The milk fat globule membrane (MFGM) is primarily composed of polar phospho- and sphingolipids, which have established biological effects on neuroplasticity. The present study aimed to investigate the effect of dietary MFGM supplementation on the neuromuscular system during post-natal development. Growing rats received dietary supplementation with bovine-derived MFGM mixtures consisting of complex milk lipids (CML), beta serum concentrate (BSC) or a complex milk lipid concentrate (CMLc) (which lacks MFGM proteins) from post-natal day 10 to day 70. Supplementation with MFGM mixtures enriched in polar lipids (BSC and CMLc, but not CML) increased the plasma phosphatidylcholine (PC) concentration, with no effect on plasma phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatidylserine (PS) or sphingomyelin (SM). In contrast, muscle PC was reduced in rats receiving supplementation with both BSC and CMLc, whereas muscle PI, PE, PS and SM remained unchanged. Rats receiving BSC and CMLc (but not CML) displayed a slow-to-fast muscle fibre type profile shift (MyHCI → MyHCIIa) that was associated with elevated expression of genes involved in myogenic differentiation (myogenic regulatory factors) and relatively fast fibre type specialisation (Myh2 and Nfatc4). Expression of neuromuscular development genes, including nerve cell markers, components of the synaptogenic agrin–LRP4 pathway and acetylcholine receptor subunits, was also increased in muscle of rats supplemented with BSC and CMLc (but not CML). These findings demonstrate that dietary supplementation with bovine-derived MFGM mixtures enriched in polar lipids can promote neuromuscular development during post-natal growth in rats, leading to shifts in adult muscle phenotype." @default.
- W2582128857 created "2017-02-03" @default.
- W2582128857 creator A5008971955 @default.
- W2582128857 creator A5015706613 @default.
- W2582128857 creator A5017839084 @default.
- W2582128857 creator A5024814922 @default.
- W2582128857 creator A5036715195 @default.
- W2582128857 creator A5041576764 @default.
- W2582128857 creator A5050740426 @default.
- W2582128857 creator A5053019982 @default.
- W2582128857 creator A5057130892 @default.
- W2582128857 creator A5072435068 @default.
- W2582128857 creator A5080059057 @default.
- W2582128857 date "2017-01-23" @default.
- W2582128857 modified "2023-09-27" @default.
- W2582128857 title "Dietary supplementation with bovine-derived milk fat globule membrane lipids promotes neuromuscular development in growing rats" @default.
- W2582128857 cites W132678722 @default.
- W2582128857 cites W1526273052 @default.
- W2582128857 cites W1595173732 @default.
- W2582128857 cites W1849347232 @default.
- W2582128857 cites W1899162081 @default.
- W2582128857 cites W1913229102 @default.
- W2582128857 cites W1966567930 @default.
- W2582128857 cites W1969019435 @default.
- W2582128857 cites W1969374356 @default.
- W2582128857 cites W1969399085 @default.
- W2582128857 cites W1970141518 @default.
- W2582128857 cites W1973217256 @default.
- W2582128857 cites W1976336779 @default.
- W2582128857 cites W1976483043 @default.
- W2582128857 cites W1976861969 @default.
- W2582128857 cites W1979165195 @default.
- W2582128857 cites W1979946797 @default.
- W2582128857 cites W1980294445 @default.
- W2582128857 cites W1983428392 @default.
- W2582128857 cites W1986153101 @default.
- W2582128857 cites W1986792090 @default.
- W2582128857 cites W1987171397 @default.
- W2582128857 cites W1989089334 @default.
- W2582128857 cites W1997324656 @default.
- W2582128857 cites W1997739354 @default.
- W2582128857 cites W1998991733 @default.
- W2582128857 cites W2000850221 @default.
- W2582128857 cites W2008229351 @default.
- W2582128857 cites W2008256279 @default.
- W2582128857 cites W2008578494 @default.
- W2582128857 cites W2011184478 @default.
- W2582128857 cites W2016568319 @default.
- W2582128857 cites W2020943703 @default.
- W2582128857 cites W2028225339 @default.
- W2582128857 cites W2034500360 @default.
- W2582128857 cites W2043445408 @default.
- W2582128857 cites W2043581075 @default.
- W2582128857 cites W2043679731 @default.
- W2582128857 cites W2044851440 @default.
- W2582128857 cites W2045291618 @default.
- W2582128857 cites W2047428077 @default.
- W2582128857 cites W2051416293 @default.
- W2582128857 cites W2057482012 @default.
- W2582128857 cites W2058030018 @default.
- W2582128857 cites W2061994372 @default.
- W2582128857 cites W2062064489 @default.
- W2582128857 cites W2062555360 @default.
- W2582128857 cites W2064231799 @default.
- W2582128857 cites W2064513924 @default.
- W2582128857 cites W2075885079 @default.
- W2582128857 cites W2080689645 @default.
- W2582128857 cites W2080757873 @default.
- W2582128857 cites W2080918733 @default.
- W2582128857 cites W2082435299 @default.
- W2582128857 cites W2083055314 @default.
- W2582128857 cites W2083482378 @default.
- W2582128857 cites W2083731603 @default.
- W2582128857 cites W2088262190 @default.
- W2582128857 cites W2089011655 @default.
- W2582128857 cites W2090278635 @default.
- W2582128857 cites W2091048816 @default.
- W2582128857 cites W2092223414 @default.
- W2582128857 cites W2093013180 @default.
- W2582128857 cites W2093540558 @default.
- W2582128857 cites W2094689830 @default.
- W2582128857 cites W2097100239 @default.
- W2582128857 cites W2102222060 @default.
- W2582128857 cites W2103415764 @default.
- W2582128857 cites W2106249467 @default.
- W2582128857 cites W2107408105 @default.
- W2582128857 cites W2107787446 @default.
- W2582128857 cites W2112956350 @default.
- W2582128857 cites W2116618150 @default.
- W2582128857 cites W2124106046 @default.
- W2582128857 cites W2124325849 @default.
- W2582128857 cites W2127693756 @default.
- W2582128857 cites W2127731961 @default.
- W2582128857 cites W2129027676 @default.
- W2582128857 cites W2130025116 @default.
- W2582128857 cites W2131636181 @default.
- W2582128857 cites W2132226748 @default.
- W2582128857 cites W2133511687 @default.
- W2582128857 cites W2141898306 @default.
- W2582128857 cites W2143528835 @default.