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- W2582161014 abstract "The efficient application of nitrogenous fertilizers is urgently required, as their excessive and inefficient use is causing substantial economic loss and environmental pollution. A significant amount of applied nitrogen in agricultural soils is lost as nitrous oxide (N2O) in the environment due to the microbial denitrification process. The widely distributed fungus Fusarium oxysporum is a major denitrifier in agricultural soils and its denitrification activity could be targeted to reduce nitrogen loss in the form of N2O from agricultural soils. Here, we report the discovery of first small molecule inhibitors of copper nitrite reductase (NirK) from F. oxysporum, which is a key enzyme in the fungal denitrification process. The inhibitors were discovered by a hierarchical in silico screening approach consisting of pharmacophore modeling and molecular docking. In vitro evaluation of F. oxysporum NirK activity revealed several pyrimidone and triazinone based compounds with potency in the low micromolar range. Some of these compounds suppressed the fungal denitrification in vivo as well. The compounds reported here could be used as starting points for the development of nitrogenous fertilizer supplements and coatings as a means to prevent nitrogen loss by targeting fungal denitrification." @default.
- W2582161014 created "2017-02-03" @default.
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- W2582161014 date "2017-02-08" @default.
- W2582161014 modified "2023-09-30" @default.
- W2582161014 title "Discovery of Fungal Denitrification Inhibitors by Targeting Copper Nitrite Reductase from <i>Fusarium oxysporum</i>" @default.
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- W2582161014 cites W1832385088 @default.
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- W2582161014 cites W1985588649 @default.
- W2582161014 cites W1985678753 @default.
- W2582161014 cites W1986987016 @default.
- W2582161014 cites W1987024060 @default.
- W2582161014 cites W1987405511 @default.
- W2582161014 cites W1992041755 @default.
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- W2582161014 cites W2000803926 @default.
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- W2582161014 cites W2058131146 @default.
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- W2582161014 cites W2152116912 @default.
- W2582161014 cites W2152362084 @default.
- W2582161014 cites W2154648013 @default.
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- W2582161014 doi "https://doi.org/10.1021/acs.jcim.6b00649" @default.
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- W2582161014 hasPublicationYear "2017" @default.
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