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• W2582203784 abstract "The purpose of this study was to examine the time course of changes in the oxygen uptake (V̇o 2 ) kinetics response subsequent to short-term exercise training (i.e., 24, 48, 72, and 120 h posttraining) and examine the relationship with the time course of changes in microvascular [deoxygenated hemoglobin concentration ([HHb])-to-V̇o 2 ratio ([HHb])/V̇o 2 )] and macrovascular [flow-mediated dilation (FMD)] O 2 delivery to the active tissues/limbs. Seven healthy older [OA; 74 ± 6 (SD) yr] and young men (YA; 25 ± 3 yr) completed three endurance cycling exercise training sessions at 70% V̇o 2peak . Moderate-intensity exercise on-transient V̇o 2 (measured breath by breath) and [HHb] (measured by near-infrared spectroscopy) were modeled with a monoexponential and normalized (0–100% of response), and the [HHb])/V̇o 2 was calculated. Ultrasound-derived FMD of the popliteal artery was assessed after 5 min of cuff occlusion. %FMD was calculated as the greatest percent change in diameter from baseline. Time constant of V̇o 2 (τV̇o 2 ) was significantly reduced in both OA (~18%) and YA (~23%) at 24 h ( P < 0.001) posttraining and remained decreased at 48 h before returning toward pretraining (PRE) values. Both groups showed a significant decrease in the [HHb])/V̇o 2 at 24, 48, and 72 h ( P = 0.001, 0.01, and 0.03, respectively) posttraining before returning toward PRE values at 120 h. %FMD followed a similar time course to that of changes in the [HHb])/V̇o 2 , being significantly greater in both OA (by ~64%) and YA (by ~26%) at 24 h ( P < 0.001), remaining increased at 48 and 72 h ( P = 0.02 and 0.03, respectively), and returning toward PRE values at 120 h. These data suggest the rate of adjustment of V̇o 2 may be constrained by O 2 availability in the active tissues." @default.
• W2582203784 created "2017-02-03" @default.
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• W2582203784 date "2017-04-01" @default.
• W2582203784 modified "2023-10-04" @default.
• W2582203784 title "Similar pattern of change in V̇<scp>o</scp>₂kinetics, vascular function, and tissue oxygen provision following an endurance training stimulus in older and young adults" @default.
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• W2582203784 doi "https://doi.org/10.1152/ajpregu.00399.2016" @default.
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