Matches in SemOpenAlex for { <https://semopenalex.org/work/W2582204466> ?p ?o ?g. }
- W2582204466 endingPage "e0170612" @default.
- W2582204466 startingPage "e0170612" @default.
- W2582204466 abstract "Streptococcus pyogenes (group A Streptococcus, or GAS) is a human pathogen that causes a wide range of diseases. For successful colonization within a variety of host niches, GAS utilizes TCSs to sense and respond to environmental changes and adapts its pathogenic traits accordingly; however, many GAS TCSs and their interactions remain uncharacterized. Here, we elucidated the roles of a poorly characterized TCS, YvqEC, and a well-studied TCS, CovRS, in 2 different GAS strain SSI-1 and JRS4, respectively. Deletion of yvqE and yvqC in JRS4 resulted in lower cell viability and abnormality of cell division when compared to the wild-type strain under standard culture conditions, demonstrating an important role for YvqEC. Furthermore, a double-deletion of yvqEC and covRS in SSI-1 and JRS4 resulted in a significantly impaired ability to survive under various stress conditions, as well as an increased sensitivity to cell wall-targeting antibiotics compared to that observed in either single mutant or wild-type strains suggesting synergistic interactions. Our findings provide new insights into the impact of poorly characterized TCS (YvqEC) and potential synergistic interactions between YvqEC and CovRS and reveal their potential role as novel therapeutic targets against GAS infection." @default.
- W2582204466 created "2017-02-03" @default.
- W2582204466 creator A5026975906 @default.
- W2582204466 creator A5035351957 @default.
- W2582204466 creator A5044929480 @default.
- W2582204466 creator A5076504113 @default.
- W2582204466 creator A5087965968 @default.
- W2582204466 date "2017-01-25" @default.
- W2582204466 modified "2023-10-18" @default.
- W2582204466 title "YvqE and CovRS of Group A Streptococcus Play a Pivotal Role in Viability and Phenotypic Adaptations to Multiple Environmental Stresses" @default.
- W2582204466 cites W1507853369 @default.
- W2582204466 cites W1906659774 @default.
- W2582204466 cites W1934585871 @default.
- W2582204466 cites W1970870093 @default.
- W2582204466 cites W1978657539 @default.
- W2582204466 cites W1980595924 @default.
- W2582204466 cites W1986438406 @default.
- W2582204466 cites W1987894090 @default.
- W2582204466 cites W1987945908 @default.
- W2582204466 cites W1990184020 @default.
- W2582204466 cites W1990890478 @default.
- W2582204466 cites W1999189021 @default.
- W2582204466 cites W1999503427 @default.
- W2582204466 cites W2005158567 @default.
- W2582204466 cites W2005489232 @default.
- W2582204466 cites W2010098507 @default.
- W2582204466 cites W2011862459 @default.
- W2582204466 cites W2032526817 @default.
- W2582204466 cites W2043213314 @default.
- W2582204466 cites W2053304303 @default.
- W2582204466 cites W2054646594 @default.
- W2582204466 cites W2057659396 @default.
- W2582204466 cites W2064904075 @default.
- W2582204466 cites W2077869269 @default.
- W2582204466 cites W2078436228 @default.
- W2582204466 cites W2085062872 @default.
- W2582204466 cites W2086086527 @default.
- W2582204466 cites W2089675028 @default.
- W2582204466 cites W2097584347 @default.
- W2582204466 cites W2098308546 @default.
- W2582204466 cites W2104305294 @default.
- W2582204466 cites W2105825563 @default.
- W2582204466 cites W2108559568 @default.
- W2582204466 cites W2114570899 @default.
- W2582204466 cites W2115025157 @default.
- W2582204466 cites W2118204420 @default.
- W2582204466 cites W2123701684 @default.
- W2582204466 cites W2126987490 @default.
- W2582204466 cites W2128912763 @default.
- W2582204466 cites W2129234138 @default.
- W2582204466 cites W2130571780 @default.
- W2582204466 cites W2131953542 @default.
- W2582204466 cites W2141516076 @default.
- W2582204466 cites W2150768239 @default.
- W2582204466 cites W2151693231 @default.
- W2582204466 cites W2152384404 @default.
- W2582204466 cites W2155976744 @default.
- W2582204466 cites W2162376398 @default.
- W2582204466 cites W2165299181 @default.
- W2582204466 cites W2168777174 @default.
- W2582204466 cites W2169589212 @default.
- W2582204466 cites W2171783565 @default.
- W2582204466 cites W578240471 @default.
- W2582204466 cites W806456143 @default.
- W2582204466 doi "https://doi.org/10.1371/journal.pone.0170612" @default.
- W2582204466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5266302" @default.
- W2582204466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28122066" @default.
- W2582204466 hasPublicationYear "2017" @default.
- W2582204466 type Work @default.
- W2582204466 sameAs 2582204466 @default.
- W2582204466 citedByCount "5" @default.
- W2582204466 countsByYear W25822044662019 @default.
- W2582204466 countsByYear W25822044662020 @default.
- W2582204466 countsByYear W25822044662021 @default.
- W2582204466 countsByYear W25822044662022 @default.
- W2582204466 crossrefType "journal-article" @default.
- W2582204466 hasAuthorship W2582204466A5026975906 @default.
- W2582204466 hasAuthorship W2582204466A5035351957 @default.
- W2582204466 hasAuthorship W2582204466A5044929480 @default.
- W2582204466 hasAuthorship W2582204466A5076504113 @default.
- W2582204466 hasAuthorship W2582204466A5087965968 @default.
- W2582204466 hasBestOaLocation W25822044661 @default.
- W2582204466 hasConcept C104317684 @default.
- W2582204466 hasConcept C105702510 @default.
- W2582204466 hasConcept C126322002 @default.
- W2582204466 hasConcept C127716648 @default.
- W2582204466 hasConcept C143065580 @default.
- W2582204466 hasConcept C24527192 @default.
- W2582204466 hasConcept C2776460866 @default.
- W2582204466 hasConcept C2778022156 @default.
- W2582204466 hasConcept C2778276568 @default.
- W2582204466 hasConcept C2779306812 @default.
- W2582204466 hasConcept C2779489039 @default.
- W2582204466 hasConcept C2780678043 @default.
- W2582204466 hasConcept C523546767 @default.
- W2582204466 hasConcept C54355233 @default.
- W2582204466 hasConcept C71924100 @default.
- W2582204466 hasConcept C86803240 @default.