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• W2582206282 abstract "Although p53 is not essential for normal embryonic development, it plays a pivotal role in many biological and pathological processes, including cell fate determination-dependent and independent events and diseases. The expression and activity of p53 largely depend on its two biological inhibitors, MDM2 and MDMX, which have been shown to form a complex in order to tightly control p53 to an undetectable level during early stages of embryonic development. However, more delicate studies using conditional gene-modification mouse models show that MDM2 and MDMX may function separately or synergistically on p53 regulation during later stages of embryonic development and adulthood in a cell and tissue-specific manner. Here, we report the role of the MDM2/MDMX-p53 pathway in pancreatic islet morphogenesis and functional maintenance, using mouse lines with specific deletion of MDM2 or MDMX in pancreatic endocrine progenitor cells. Interestingly, deletion of MDM2 results in defects of embryonic endocrine pancreas development, followed by neonatal hyperglycemia and lethality, by inducing pancreatic progenitor cell apoptosis and inhibiting cell proliferation. However, unlike MDM2-knockout animals, mice lacking MDMX in endocrine progenitor cells develop normally. But, surprisingly, the survival rate of adult MDMX-knockout mice drastically declines compared to control mice, as blockage of neonatal development of endocrine pancreas by inhibition of cell proliferation and subsequent islet dysfunction and hyperglycemia eventually lead to type 1 diabetes-like disease with advanced diabetic nephropathy. As expected, both MDM2 and MDMX deletion-caused pancreatic defects are completely rescued by loss of p53, verifying the crucial role of the MDM2 and/or MDMX in regulating p53 in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas. Also, our study suggests a possible mouse model of advanced diabetic nephropathy, which is complementary to other established diabetic models and perhaps useful for the development of anti-diabetes therapies." @default.
• W2582206282 created "2017-02-03" @default.
• W2582206282 creator A5003957341 @default.
• W2582206282 creator A5043299001 @default.
• W2582206282 creator A5057269185 @default.
• W2582206282 creator A5061151351 @default.
• W2582206282 date "2017-03-01" @default.
• W2582206282 modified "2023-10-05" @default.
• W2582206282 title "Monitoring p53 by MDM2 and MDMX is required for endocrine pancreas development and function in a spatio-temporal manner" @default.
• W2582206282 cites W1598741049 @default.
• W2582206282 cites W1724512254 @default.
• W2582206282 cites W1822460389 @default.
• W2582206282 cites W1925535727 @default.
• W2582206282 cites W1956367884 @default.
• W2582206282 cites W1965173366 @default.
• W2582206282 cites W1965244636 @default.
• W2582206282 cites W1967632402 @default.
• W2582206282 cites W1968045768 @default.
• W2582206282 cites W1968631483 @default.
• W2582206282 cites W1976633722 @default.
• W2582206282 cites W1978006133 @default.
• W2582206282 cites W1978583076 @default.
• W2582206282 cites W1981299401 @default.
• W2582206282 cites W1983222638 @default.
• W2582206282 cites W1986811533 @default.
• W2582206282 cites W1987292778 @default.
• W2582206282 cites W1992307025 @default.
• W2582206282 cites W1994655355 @default.
• W2582206282 cites W2003971548 @default.
• W2582206282 cites W2004193166 @default.
• W2582206282 cites W2006565856 @default.
• W2582206282 cites W2007003036 @default.
• W2582206282 cites W2011735401 @default.
• W2582206282 cites W2013939152 @default.
• W2582206282 cites W2021410897 @default.
• W2582206282 cites W2025722611 @default.
• W2582206282 cites W2030223334 @default.
• W2582206282 cites W2030494575 @default.
• W2582206282 cites W2031276095 @default.
• W2582206282 cites W2032567347 @default.
• W2582206282 cites W2032739542 @default.
• W2582206282 cites W2039324591 @default.
• W2582206282 cites W2043411325 @default.
• W2582206282 cites W2046097974 @default.
• W2582206282 cites W2049667730 @default.
• W2582206282 cites W2051282357 @default.
• W2582206282 cites W2052810389 @default.
• W2582206282 cites W2054749109 @default.
• W2582206282 cites W2056840717 @default.
• W2582206282 cites W2057057259 @default.
• W2582206282 cites W2061846490 @default.
• W2582206282 cites W2062537607 @default.
• W2582206282 cites W2064119981 @default.
• W2582206282 cites W2066163561 @default.
• W2582206282 cites W2068196972 @default.
• W2582206282 cites W2070432942 @default.
• W2582206282 cites W2076451420 @default.
• W2582206282 cites W2081596143 @default.
• W2582206282 cites W2088740611 @default.
• W2582206282 cites W2089323301 @default.
• W2582206282 cites W2094288585 @default.
• W2582206282 cites W2094673564 @default.
• W2582206282 cites W2099907467 @default.
• W2582206282 cites W2103678021 @default.
• W2582206282 cites W2112706571 @default.
• W2582206282 cites W2116918328 @default.
• W2582206282 cites W2125827510 @default.
• W2582206282 cites W2126679757 @default.
• W2582206282 cites W2128306207 @default.
• W2582206282 cites W2129338507 @default.
• W2582206282 cites W2129731670 @default.
• W2582206282 cites W2133528282 @default.
• W2582206282 cites W2134321528 @default.
• W2582206282 cites W2138121862 @default.
• W2582206282 cites W2138846538 @default.
• W2582206282 cites W2139909211 @default.
• W2582206282 cites W2142180745 @default.
• W2582206282 cites W2146792253 @default.
• W2582206282 cites W2148652246 @default.
• W2582206282 cites W2149351270 @default.
• W2582206282 cites W2150367899 @default.
• W2582206282 cites W2151199834 @default.
• W2582206282 cites W2156760050 @default.
• W2582206282 cites W2160723659 @default.
• W2582206282 cites W2161828378 @default.
• W2582206282 cites W2279231838 @default.
• W2582206282 cites W2292304354 @default.
• W2582206282 cites W2319034424 @default.
• W2582206282 cites W2915464224 @default.
• W2582206282 cites W4211246765 @default.
• W2582206282 cites W2105000888 @default.
• W2582206282 doi "https://doi.org/10.1016/j.ydbio.2017.01.014" @default.
• W2582206282 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5328981" @default.
• W2582206282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28118981" @default.
• W2582206282 hasPublicationYear "2017" @default.
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