Matches in SemOpenAlex for { <https://semopenalex.org/work/W2582293990> ?p ?o ?g. }
- W2582293990 endingPage "87" @default.
- W2582293990 startingPage "65" @default.
- W2582293990 abstract "Cadmium (Cd) is an environmental toxicant of widespread exposure and pervasive toxicity. Absorption, systemic transport and uptake of Cd are mediated by metal transporters that the body uses for acquisition of physiologically-essential elements, notably of iron, zinc and calcium. Currently, human exposure to Cd is known to damage the kidneys, especially the proximal tubular cells that actively reabsorb Cd along with zinc, glucose and amino acids in the glomerular filtrate. Severe kidney damage, glycosuria and proteinuria are known outcomes after high dietary Cd intake (> 200 µg/day). Dietary Cd intake of 10-30 µg/day has been linked with reduced tubular reabsorption, chronic kidney disease, hypertension, coronary arterial and peripheral arterial diseases, macular degeneration, obesity-independent diabetes, and cancer. The links between diabetes, hypertension and end stage kidney disease (ESKD) are indisputable. ESKD requires dialysis or kidney transplant, an immense health care cost. This review adds to these connections by presenting the synergism of kidney Cd toxicity on blood pressure control and glucose homeostasis. Blood pressure control is mediated at least in part by cytochrome P450 (CYP) enzymes such as CYP4A11 and CYP4F2 that produce 20-hydroxyeicosatetraenoic acid (20-HETE), involved in salt balance in the kidney, and all are known to be altered during Cd exposure. The potential effects of Cd exposure on glucose reabsorption, inflammation, oxidative stress, and heme oxygenase activity are highlighted. The information presented offers strategies for mitigation of toxic effects of Cd through minimization of the food-chain transfer of Cd, and modulation of mechanistic pathways altered by Cd exposure." @default.
- W2582293990 created "2017-02-03" @default.
- W2582293990 creator A5001910883 @default.
- W2582293990 creator A5038188646 @default.
- W2582293990 creator A5045147978 @default.
- W2582293990 date "2017-01-01" @default.
- W2582293990 modified "2023-10-14" @default.
- W2582293990 title "Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm" @default.
- W2582293990 cites W1061159978 @default.
- W2582293990 cites W1503110580 @default.
- W2582293990 cites W1558823847 @default.
- W2582293990 cites W1568628619 @default.
- W2582293990 cites W1927887680 @default.
- W2582293990 cites W1943096387 @default.
- W2582293990 cites W1963935918 @default.
- W2582293990 cites W1964943798 @default.
- W2582293990 cites W1968125267 @default.
- W2582293990 cites W1970058939 @default.
- W2582293990 cites W1971976947 @default.
- W2582293990 cites W1972435161 @default.
- W2582293990 cites W1976818768 @default.
- W2582293990 cites W1979837064 @default.
- W2582293990 cites W1981053255 @default.
- W2582293990 cites W1986287389 @default.
- W2582293990 cites W1987842495 @default.
- W2582293990 cites W1989805864 @default.
- W2582293990 cites W1990790739 @default.
- W2582293990 cites W1991215928 @default.
- W2582293990 cites W1991627905 @default.
- W2582293990 cites W1992316947 @default.
- W2582293990 cites W1992509627 @default.
- W2582293990 cites W1992778247 @default.
- W2582293990 cites W1992919600 @default.
- W2582293990 cites W1993166724 @default.
- W2582293990 cites W1996026179 @default.
- W2582293990 cites W1996259140 @default.
- W2582293990 cites W1996693631 @default.
- W2582293990 cites W1996726475 @default.
- W2582293990 cites W2002194181 @default.
- W2582293990 cites W2002924950 @default.
- W2582293990 cites W2003310479 @default.
- W2582293990 cites W2003522179 @default.
- W2582293990 cites W2005370325 @default.
- W2582293990 cites W2008895137 @default.
- W2582293990 cites W2011039014 @default.
- W2582293990 cites W2014739271 @default.
- W2582293990 cites W2014818573 @default.
- W2582293990 cites W2016456530 @default.
- W2582293990 cites W2017196485 @default.
- W2582293990 cites W2017275974 @default.
- W2582293990 cites W2018268603 @default.
- W2582293990 cites W2018644811 @default.
- W2582293990 cites W2021224958 @default.
- W2582293990 cites W2023380061 @default.
- W2582293990 cites W2024650900 @default.
- W2582293990 cites W2024743583 @default.
- W2582293990 cites W2025540496 @default.
- W2582293990 cites W2027521776 @default.
- W2582293990 cites W2030452539 @default.
- W2582293990 cites W2031987667 @default.
- W2582293990 cites W2033968745 @default.
- W2582293990 cites W2035547952 @default.
- W2582293990 cites W2036333816 @default.
- W2582293990 cites W2036474706 @default.
- W2582293990 cites W2040592785 @default.
- W2582293990 cites W2041645449 @default.
- W2582293990 cites W2043127619 @default.
- W2582293990 cites W2051837475 @default.
- W2582293990 cites W2053147788 @default.
- W2582293990 cites W2053770440 @default.
- W2582293990 cites W2055410774 @default.
- W2582293990 cites W2060257199 @default.
- W2582293990 cites W2060848725 @default.
- W2582293990 cites W2061139736 @default.
- W2582293990 cites W2062084630 @default.
- W2582293990 cites W2062199105 @default.
- W2582293990 cites W2062214745 @default.
- W2582293990 cites W2062310627 @default.
- W2582293990 cites W2064509511 @default.
- W2582293990 cites W2064539814 @default.
- W2582293990 cites W2065329019 @default.
- W2582293990 cites W2066042413 @default.
- W2582293990 cites W2069415594 @default.
- W2582293990 cites W2071272097 @default.
- W2582293990 cites W2074203821 @default.
- W2582293990 cites W2074525099 @default.
- W2582293990 cites W2076706873 @default.
- W2582293990 cites W2077560124 @default.
- W2582293990 cites W2079576230 @default.
- W2582293990 cites W2079633658 @default.
- W2582293990 cites W2081258904 @default.
- W2582293990 cites W2082089700 @default.
- W2582293990 cites W2082645779 @default.
- W2582293990 cites W2083953556 @default.
- W2582293990 cites W2084757815 @default.
- W2582293990 cites W2088870649 @default.
- W2582293990 cites W2089247509 @default.
- W2582293990 cites W2092345183 @default.