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- W2582360839 abstract "OBJECTIVE: To analyze the use of analgesics in individuals with pre-manifest Huntington disease (HD) participating in PREQUEL. BACKGROUND: PREQUEL is the first multi-center interventional trial in subjects with pre-manifest HD. Depression, known to be increased in pre-manifest HD, is associated with chronic pain and analgesic use. The use of analgesics in the pre-manifest HD population has not been previously investigated. DESIGN/METHODS: PREQUEL participants are adults who have tested positive for the HD gene expansion (>36 CAGn repeats) but are deemed pre-manifest (prior to motor diagnosis). Participants9 psychiatric features were assessed with the Beck Depression Inventory II and the behavioral component of the Unified Huntington9s Disease Rating Scale. An analysis was performed on the use of analgesics, as reported at the initial baseline study visit. The association between analgesic use and psychiatric and psychosocial features was explored. RESULTS: PREQUEL enrolled 90 adults at 13 U.S. sites from 2/2010 - 9/2011. The use of analgesics was reported in 49% of subjects, (compared to 14% of the general adult population). Reported analgesics were primarily non-opioid agents, most commonly used for the management of cephalgia (37%) and non-cepaphalgic focal pain (29%). Analgesic use was associated with a history of drug abuse (p=0.033) and self-reported anxiety severity (p=0.017), but not with other psychiatric features, a history of alcohol abuse or the use of psychotropic medications (seen in 53%). CONCLUSIONS: The high prevalence of analgesic use in the PREQUEL cohort suggests that pain may be a previously-unrecognized feature of pre-manifest HD. The association with drug abuse raises the concern that illicit substances are used to self-medicate pain symptoms in this population. Further investigation into the use of analgesics in pre-manifest HD is warranted. Supported by: National Institute of Neurological Disorders and Stroke (NINDS). Disclosure: Dr. Killoran has nothing to disclose. Dr. Biglan has received personal compensation for activities with Lundbeck and Theravance Inc. Dr. Biglan has received research support from Presbyterian Home of Central New York, Susquehana Nursing and Rehabilitation Center, Marvell Inc, and Google. Dr. Julian-Baros has nothing to disclose. Dr. Yoritomo has nothing to disclose. Dr. Ross has nothing to disclose." @default.
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- W2582360839 date "2013-02-12" @default.
- W2582360839 modified "2023-09-26" @default.
- W2582360839 title "Analysis of Analgesic Use in Pre-Manifest Huntington Disease (P07.208)" @default.
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