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• W2582396240 endingPage "198" @default.
• W2582396240 startingPage "173" @default.
• W2582396240 abstract "Transient receptor potential vanilloid-1 (TRPV1) is a member of the TRP family of channels that are responsible for nociceptive, thermal, and mechanical sensations. Originally associated exclusively with sensory neurons, TRPV1 is now known to be present in almost all organs, including cells of the immune system, where TRPV1 has been shown to play a pivotal role in inflammation and immunity. Monocytes, macrophages, and dendritic cells express TRPV1, with both mouse and human studies suggesting that TRPV1 activation protects against endotoxin-induced inflammation. In contrast, TRPV1 (and other TRP channels) appears to be required for T-cell receptor activation by mitogens. Additionally, studies in cell lines derived from hematological and other malignancies suggest altered expression/function of TRPV1 might serve as a target for novel cytotoxic therapies." @default.
• W2582396240 created "2017-02-03" @default.
• W2582396240 creator A5020496381 @default.
• W2582396240 creator A5038997158 @default.
• W2582396240 creator A5072022479 @default.
• W2582396240 date "2017-01-01" @default.
• W2582396240 modified "2023-10-03" @default.
• W2582396240 title "TRPV1 Channels in Immune Cells and Hematological Malignancies" @default.
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