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• W2582426955 abstract "Aims To compare the safety and efficacy of a simpler titration algorithm for insulin degludec/liraglutide ( IDegLira ) with that used in previous DUAL trials in insulin‐naïve patients with type 2 diabetes. Research design and methods This 32‐week, open‐label, non‐inferiority trial randomized adults with type 2 diabetes uncontrolled on metformin ± pioglitazone to receive IDegLira , titrated either once weekly, based on the mean of 2 pre‐breakfast plasma glucose ( PG ) readings (n = 210), or twice weekly, based on the mean of 3 pre‐breakfast PG readings (n = 210). Results Mean HbA1c decreased from 8.2% (65 mmol/mol) to 6.1% (43 mmol/mol) with once‐weekly titration and from 8.1% (65 mmol/mol) to 6.0% (42 mmol/mol) with twice‐weekly titration; non‐inferiority was confirmed (estimated treatment difference: 0.12% [−0.04; 0.28] 95% CI , 1.30 mmol/mol [−0.41; 3.01] 95% CI ). Approximately 90% of patients achieved HbA1c < 7% in each arm. Mean fasting PG was similar after 32 weeks. Weight change was −1.0 kg vs −2.0 kg for once‐weekly vs twice‐weekly titration. Rates of severe or blood glucose‐confirmed symptomatic hypoglycaemia were low in both arms: 0.16 events/patient‐year of exposure ( PYE ) for once‐weekly, 0.76 events/ PYE for twice‐weekly titration. Mean IDegLira dose at 32 weeks was 41 dose steps (41 U IDeg /1.48 mg L ira) for both arms. Overall adverse event rates were 207.8 and 241.3 events/100 PYE with once‐weekly and twice‐weekly titration, respectively. Conclusion A pragmatic titration algorithm with once‐weekly adjustments based on 2 PG readings resulted in a safety and glycaemic efficacy profile similar to that with twice‐weekly adjustments based on 3 preceding PG values in insulin‐naïve patients." @default.
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• W2582426955 date "2017-03-03" @default.
• W2582426955 modified "2023-10-16" @default.
• W2582426955 title "Safety and efficacy of IDegLira titrated once weekly versus twice weekly in patients with type 2 diabetes uncontrolled on oral antidiabetic drugs: DUAL VI randomized clinical trial" @default.
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• W2582426955 doi "https://doi.org/10.1111/dom.12892" @default.
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