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- W2582503005 abstract "Interlukin-33 (IL-33) is a novel cytokine of the IL-1 superfamily that is expressed mainly in stromal cells, such as epithelial and endothelial cells. It is believed to be involved in inflammation and carcinogenesis. Recently we have reported that IL-33 is up regulated in azoxymethane-dextran sulfate sodium salt (AOM/DSS)- induced in colitis in mice. In this study we have investigated the biological activity of IL-33 in cells migration in IEC-6 epithelial cells. Our wound healing assay demonstrated that IL-33 significantly enhanced cell migration towards the wound edges compared with the untreated control cells. Trans-well migration assay in presence of cells culture and wound stimulation in the lower chamber, IL-33 exhibited significant chemoattractant activity for the cells migration. On the other hand, in absence of cells culture and wound stimulation in the lower chamber, IL-33 neither produced remarkable chemokine, nor chemoattractant activity for the cells migration. These findings indicate that IL-33 interacts with wound-stimulated soluble cellular product(s) in the lower chamber to accelerate cell migration.Asian J. Med. Biol. Res. December 2016, 2(4): 577-581" @default.
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- W2582503005 date "2017-01-23" @default.
- W2582503005 modified "2023-10-01" @default.
- W2582503005 title "Interleukin-33, an interleukin-1 like cytokine accelerates cell migration in IEC-6 cells" @default.
- W2582503005 doi "https://doi.org/10.3329/ajmbr.v2i4.30999" @default.
- W2582503005 hasPublicationYear "2017" @default.
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