FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2582581815> ?p ?o ?g. }

• W2582581815 endingPage "27" @default.
• W2582581815 startingPage "19" @default.
• W2582581815 abstract "Anaplastic large cell lymphomas (ALCLs) are CD30-positive T-cell non-Hodgkin lymphomas that bear chromosomal rearrangements of the TP53 homologue TP63 in a subset of cases that demonstrate aggressive clinical behavior. In the present study, we examined the relationship between p63 protein expression by immunohistochemistry and the results of fluorescence in situ hybridization using TP63 probes in 116 ALCLs. We also determined the relative expression of full-length TAp63 and truncated ΔNp63 isoforms (eg, p40) in ALCL cell lines and a subset of clinical cases. Overall, 35.3% of ALCLs were positive for p63 protein. Primary cutaneous and anaplastic lymphoma kinase–negative ALCLs were positive more frequently than anaplastic lymphoma kinase–positive ALCLs (P = .0034). As previously reported, cases with TP63 gene rearrangements expressed p63 uniformly. p63 expression in nonrearranged cases was associated with extra copies of TP63 on 3q28 (P < .0001). Extra copies of TP63 correlated with extra copies of the DUSP22 locus on 6p25.3 (P < .0001). Results of immunohistochemistry, Western blotting, and RNA sequencing indicated that p63 expression in nonrearranged cases was entirely attributable to TAp63 isoforms. Taken together, these findings indicate that ALCLs without TP63 rearrangements may express TAp63 isoforms of p63 and that this expression is associated with extra copies of TP63, probably due to widespread genomic copy number abnormalities rather than focal gains. Immunohistochemistry for p63 in ALCL is not specific for TP63 rearrangements but is useful clinically as a screening test to select cases for further testing by fluorescence in situ hybridization. Immunohistochemistry for ΔNp63 (p40) is not informative in the evaluation of ALCL." @default.
• W2582581815 created "2017-02-03" @default.
• W2582581815 creator A5004446140 @default.
• W2582581815 creator A5019229900 @default.
• W2582581815 creator A5028359701 @default.
• W2582581815 creator A5057021891 @default.
• W2582581815 creator A5059729547 @default.
• W2582581815 creator A5064721834 @default.
• W2582581815 creator A5088357128 @default.
• W2582581815 creator A5089582418 @default.
• W2582581815 creator A5090406453 @default.
• W2582581815 creator A5091466413 @default.
• W2582581815 date "2017-06-01" @default.
• W2582581815 modified "2023-09-27" @default.
• W2582581815 title "Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping" @default.
• W2582581815 cites W1258570584 @default.
• W2582581815 cites W1908911888 @default.
• W2582581815 cites W1915589771 @default.
• W2582581815 cites W1964794539 @default.
• W2582581815 cites W1973528379 @default.
• W2582581815 cites W1985394656 @default.
• W2582581815 cites W1987490243 @default.
• W2582581815 cites W1988080979 @default.
• W2582581815 cites W1992099424 @default.
• W2582581815 cites W1992782604 @default.
• W2582581815 cites W2000183232 @default.
• W2582581815 cites W2000434352 @default.
• W2582581815 cites W2009554628 @default.
• W2582581815 cites W2014938226 @default.
• W2582581815 cites W2015521789 @default.
• W2582581815 cites W2034654045 @default.
• W2582581815 cites W2047861432 @default.
• W2582581815 cites W2049143215 @default.
• W2582581815 cites W2054981415 @default.
• W2582581815 cites W2063751533 @default.
• W2582581815 cites W2085012601 @default.
• W2582581815 cites W2087224116 @default.
• W2582581815 cites W2100810085 @default.
• W2582581815 cites W2134906851 @default.
• W2582581815 cites W2174906016 @default.
• W2582581815 cites W2278479675 @default.
• W2582581815 cites W2310716991 @default.
• W2582581815 cites W2324023748 @default.
• W2582581815 cites W2442366440 @default.
• W2582581815 cites W4234821789 @default.
• W2582581815 doi "https://doi.org/10.1016/j.humpath.2017.01.003" @default.
• W2582581815 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5518937" @default.
• W2582581815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28153507" @default.
• W2582581815 hasPublicationYear "2017" @default.
• W2582581815 type Work @default.
• W2582581815 sameAs 2582581815 @default.
• W2582581815 citedByCount "39" @default.
• W2582581815 countsByYear W25825818152017 @default.
• W2582581815 countsByYear W25825818152018 @default.
• W2582581815 countsByYear W25825818152019 @default.
• W2582581815 countsByYear W25825818152020 @default.
• W2582581815 countsByYear W25825818152021 @default.
• W2582581815 countsByYear W25825818152022 @default.
• W2582581815 countsByYear W25825818152023 @default.
• W2582581815 crossrefType "journal-article" @default.
• W2582581815 hasAuthorship W2582581815A5004446140 @default.
• W2582581815 hasAuthorship W2582581815A5019229900 @default.
• W2582581815 hasAuthorship W2582581815A5028359701 @default.
• W2582581815 hasAuthorship W2582581815A5057021891 @default.
• W2582581815 hasAuthorship W2582581815A5059729547 @default.
• W2582581815 hasAuthorship W2582581815A5064721834 @default.
• W2582581815 hasAuthorship W2582581815A5088357128 @default.
• W2582581815 hasAuthorship W2582581815A5089582418 @default.
• W2582581815 hasAuthorship W2582581815A5090406453 @default.
• W2582581815 hasAuthorship W2582581815A5091466413 @default.
• W2582581815 hasBestOaLocation W25825818152 @default.
• W2582581815 hasConcept C104317684 @default.
• W2582581815 hasConcept C117643217 @default.
• W2582581815 hasConcept C142724271 @default.
• W2582581815 hasConcept C203014093 @default.
• W2582581815 hasConcept C204232928 @default.
• W2582581815 hasConcept C2776090121 @default.
• W2582581815 hasConcept C2776232967 @default.
• W2582581815 hasConcept C2776256026 @default.
• W2582581815 hasConcept C2777542201 @default.
• W2582581815 hasConcept C2777872185 @default.
• W2582581815 hasConcept C2777891184 @default.
• W2582581815 hasConcept C2779338263 @default.
• W2582581815 hasConcept C30481170 @default.
• W2582581815 hasConcept C502942594 @default.
• W2582581815 hasConcept C53345823 @default.
• W2582581815 hasConcept C54355233 @default.
• W2582581815 hasConcept C71924100 @default.
• W2582581815 hasConcept C84597430 @default.
• W2582581815 hasConcept C86803240 @default.
• W2582581815 hasConcept C8891405 @default.
• W2582581815 hasConceptScore W2582581815C104317684 @default.
• W2582581815 hasConceptScore W2582581815C117643217 @default.
• W2582581815 hasConceptScore W2582581815C142724271 @default.
• W2582581815 hasConceptScore W2582581815C203014093 @default.
• W2582581815 hasConceptScore W2582581815C204232928 @default.
• W2582581815 hasConceptScore W2582581815C2776090121 @default.
• W2582581815 hasConceptScore W2582581815C2776232967 @default.

• next