FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2582603587> ?p ?o ?g. }

• W2582603587 abstract "Epidemiologic studies show an inverse correlation between garlic consumption and progression of cardiovascular disease. However, the molecular basis for the beneficial effect of garlic on the heart is not known. Therefore, the objective of the present study was to (1) investigate the effect of raw garlic on isoproterenol (Iso) induced cardiac hypertrophy (2) find the active metabolites of garlic responsible for the beneficial effect. Cardiac hypertrophy was induced in rats by subcutaneous single injection of Iso 5 mg kg-1 day-1 for 15 days and the effect of garlic (250 mg/kg/day orally) was evaluated. Garlic metabolites in in vivo were identified by LC/MS study. The effect of garlic and its metabolites were evaluated against hypertrophy in H9C2 cells. Garlic normalized cardiac oxidative stress after Iso administration. Cardiac pathology and mitochondrial enzyme activities were improved in hypertrophy heart after garlic administration. Decreased Na+/K+-ATPase protein level that observed in hypertrophy heart was increased after garlic administration. We identified three garlic metabolites in rat serum. To confirm the role of garlic metabolites on cardiac hypertrophy, Na+/K+-ATPase expression and intracellular calcium levels were measured after treating H9C2 cells with raw garlic and two of its active metabolites, allyl methyl sulfide and allyl methyl sulfoxide. Raw garlic and both metabolites increased Na+/K+-ATPase protein level and decreased intracellular calcium levels and cell size in Iso treated H9C2 cells. This antihypertrophic effect of garlic and its sulfur metabolites were lost in H9C2 cells in presence of Na+/K+-ATPase inhibitor. In conclusion, garlic and its active metabolites increased Na+/K+-ATPase in rat heart, and attenuated cardiac hypertrophy and associated remodeling. Our data suggest that identified new garlic metabolites may be useful for therapeutic intervention against cardiac hypertrophy." @default.
• W2582603587 created "2017-02-03" @default.
• W2582603587 creator A5000861409 @default.
• W2582603587 creator A5018499913 @default.
• W2582603587 creator A5018608283 @default.
• W2582603587 creator A5041076829 @default.
• W2582603587 creator A5057512177 @default.
• W2582603587 creator A5078189560 @default.
• W2582603587 date "2017-01-30" @default.
• W2582603587 modified "2023-09-30" @default.
• W2582603587 title "Novel Sulfur Metabolites of Garlic Attenuate Cardiac Hypertrophy and Remodeling through Induction of Na+/K+-ATPase Expression" @default.
• W2582603587 cites W1566255459 @default.
• W2582603587 cites W1904312815 @default.
• W2582603587 cites W1965934331 @default.
• W2582603587 cites W1976934423 @default.
• W2582603587 cites W1984732206 @default.
• W2582603587 cites W1987097693 @default.
• W2582603587 cites W1989541200 @default.
• W2582603587 cites W2004560046 @default.
• W2582603587 cites W2007478152 @default.
• W2582603587 cites W2030793653 @default.
• W2582603587 cites W2030845966 @default.
• W2582603587 cites W2031822790 @default.
• W2582603587 cites W2050897300 @default.
• W2582603587 cites W2058824097 @default.
• W2582603587 cites W2072185022 @default.
• W2582603587 cites W2072554732 @default.
• W2582603587 cites W2082779145 @default.
• W2582603587 cites W2085927442 @default.
• W2582603587 cites W2090549934 @default.
• W2582603587 cites W2100708810 @default.
• W2582603587 cites W2103416697 @default.
• W2582603587 cites W2112705286 @default.
• W2582603587 cites W2128370892 @default.
• W2582603587 cites W2129439677 @default.
• W2582603587 cites W2130120331 @default.
• W2582603587 cites W2141663828 @default.
• W2582603587 cites W2147081693 @default.
• W2582603587 cites W2147786276 @default.
• W2582603587 cites W2150351630 @default.
• W2582603587 cites W2157939807 @default.
• W2582603587 cites W2158641193 @default.
• W2582603587 cites W2163137554 @default.
• W2582603587 cites W2169884492 @default.
• W2582603587 cites W2181820224 @default.
• W2582603587 cites W2320349116 @default.
• W2582603587 cites W2400027002 @default.
• W2582603587 cites W4247088117 @default.
• W2582603587 doi "https://doi.org/10.3389/fphar.2017.00018" @default.
• W2582603587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5276815" @default.
• W2582603587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28194108" @default.
• W2582603587 hasPublicationYear "2017" @default.
• W2582603587 type Work @default.
• W2582603587 sameAs 2582603587 @default.
• W2582603587 citedByCount "33" @default.
• W2582603587 countsByYear W25826035872017 @default.
• W2582603587 countsByYear W25826035872018 @default.
• W2582603587 countsByYear W25826035872019 @default.
• W2582603587 countsByYear W25826035872020 @default.
• W2582603587 countsByYear W25826035872021 @default.
• W2582603587 countsByYear W25826035872022 @default.
• W2582603587 countsByYear W25826035872023 @default.
• W2582603587 crossrefType "journal-article" @default.
• W2582603587 hasAuthorship W2582603587A5000861409 @default.
• W2582603587 hasAuthorship W2582603587A5018499913 @default.
• W2582603587 hasAuthorship W2582603587A5018608283 @default.
• W2582603587 hasAuthorship W2582603587A5041076829 @default.
• W2582603587 hasAuthorship W2582603587A5057512177 @default.
• W2582603587 hasAuthorship W2582603587A5078189560 @default.
• W2582603587 hasBestOaLocation W25826035871 @default.
• W2582603587 hasConcept C126322002 @default.
• W2582603587 hasConcept C134018914 @default.
• W2582603587 hasConcept C167414201 @default.
• W2582603587 hasConcept C181199279 @default.
• W2582603587 hasConcept C185592680 @default.
• W2582603587 hasConcept C23265538 @default.
• W2582603587 hasConcept C2776151105 @default.
• W2582603587 hasConcept C2991964360 @default.
• W2582603587 hasConcept C55493867 @default.
• W2582603587 hasConcept C59822182 @default.
• W2582603587 hasConcept C71924100 @default.
• W2582603587 hasConcept C79879829 @default.
• W2582603587 hasConcept C86803240 @default.
• W2582603587 hasConcept C98274493 @default.
• W2582603587 hasConceptScore W2582603587C126322002 @default.
• W2582603587 hasConceptScore W2582603587C134018914 @default.
• W2582603587 hasConceptScore W2582603587C167414201 @default.
• W2582603587 hasConceptScore W2582603587C181199279 @default.
• W2582603587 hasConceptScore W2582603587C185592680 @default.
• W2582603587 hasConceptScore W2582603587C23265538 @default.
• W2582603587 hasConceptScore W2582603587C2776151105 @default.
• W2582603587 hasConceptScore W2582603587C2991964360 @default.
• W2582603587 hasConceptScore W2582603587C55493867 @default.
• W2582603587 hasConceptScore W2582603587C59822182 @default.
• W2582603587 hasConceptScore W2582603587C71924100 @default.
• W2582603587 hasConceptScore W2582603587C79879829 @default.
• W2582603587 hasConceptScore W2582603587C86803240 @default.
• W2582603587 hasConceptScore W2582603587C98274493 @default.
• W2582603587 hasLocation W25826035871 @default.
• W2582603587 hasLocation W25826035872 @default.

• next