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- W2582608315 endingPage "1555" @default.
- W2582608315 startingPage "1543" @default.
- W2582608315 abstract "Trypanosoma cruzi and Leishmania spp. are protozoa of the Trypanosomatidae family, being the etiological agents of two widespread parasitic diseases, Chagas disease and leishmaniasis, respectively. Both parasites are the focus of worldwide research with the aim to find effective and less toxic drugs than the few ones available so far, and for controlling the spread of the diseases. Carbonic anhydrases (CAs, EC 4.2.1.1) belonging to the α- and β-class were recently identified in these protozoans and several studies suggested that they could be new targets for drug development. Sulfonamide, thiol and hydroxamate inhibitors effectively inhibited the α-CA from T. cruzi (TcCA) and the β-CA from L. donovani chagasi (LdccCA) in vitro, and some of them also showed in vivo efficacy in inhibiting the growth of the parasites in animal models of Chagas disease and leishmaniasis. As few therapeutic options are presently available for these orphan diseases, protozoan CA inhibition may represent a novel strategy to address this stringent health problem." @default.
- W2582608315 created "2017-02-03" @default.
- W2582608315 creator A5023495344 @default.
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- W2582608315 creator A5035013697 @default.
- W2582608315 creator A5046236889 @default.
- W2582608315 creator A5051007113 @default.
- W2582608315 date "2017-03-01" @default.
- W2582608315 modified "2023-09-27" @default.
- W2582608315 title "Carbonic anhydrases from Trypanosoma and Leishmania as anti-protozoan drug targets" @default.
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