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• W2582687375 endingPage "gkw1361" @default.
• W2582687375 startingPage "gkw1361" @default.
• W2582687375 abstract "A major gap in our understanding of ribosome assembly is knowing the precise function of each of the ∼200 assembly factors. The steps in subunit assembly in which these factors participate have been examined for the most part by depleting each protein from cells. Depletion of the assembly factor Erb1 prevents stable assembly of seven other interdependent assembly factors with pre-60S subunits, resulting in turnover of early preribosomes, before the ITS1 spacer can be removed from 27SA3 pre-rRNA. To investigate more specific functions of Erb1, we constructed eight internal deletions of 40-60 amino acid residues each, spanning the amino-terminal half of Erb1. The erb1Δ161-200 and erb1Δ201-245 deletion mutations block a later step than depletion of Erb1, namely cleavage of the C2 site that initiates removal of the ITS2 spacer. Two other remodeling events fail to occur in these erb1 mutants: association of twelve different assembly factors with domain V of 25S rRNA, including the neighborhood surrounding the peptidyl transferase center, and stable association of ribosomal proteins with rRNA surrounding the polypeptide exit tunnel. This suggests that successful initiation of construction of these functional centers is a checkpoint for committing to spacer removal." @default.
• W2582687375 created "2017-02-03" @default.
• W2582687375 creator A5052382385 @default.
• W2582687375 creator A5071953992 @default.
• W2582687375 creator A5088881927 @default.
• W2582687375 date "2017-01-23" @default.
• W2582687375 modified "2023-09-26" @default.
• W2582687375 title "The assembly factor Erb1 functions in multiple remodeling events during 60S ribosomal subunit assembly inS. cerevisiae" @default.
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• W2582687375 doi "https://doi.org/10.1093/nar/gkw1361" @default.
• W2582687375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5416829" @default.
• W2582687375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28115637" @default.
• W2582687375 hasPublicationYear "2017" @default.
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