Matches in SemOpenAlex for { <https://semopenalex.org/work/W2582809270> ?p ?o ?g. }
- W2582809270 endingPage "40" @default.
- W2582809270 startingPage "30" @default.
- W2582809270 abstract "Despite advances in cardiovascular biology and medical therapy, heart disorders are the leading cause of death worldwide. Cell-based regenerative therapies become a promising treatment for patients affected by heart failure, but also underline the need for reproducible results in preclinical and clinical studies for safety and efficacy. Enthusiasm has been tempered by poor engraftment, survival and differentiation of the injected adult stem cells. The crucial challenge is identification and selection of the most suitable stem cell type for cardiac regenerative medicine. Human pluripotent stem cells (PSCs) have emerged as attractive cell source to obtain cardiomyocytes (CMs), with potential applications, including drug discovery and toxicity screening, disease modelling and innovative cell therapies. Lessons from embryology offered important insights into the development of stem cell-derived CMs. However, the generation of a CM population, uniform in cardiac subtype, adult maturation and functional properties, is highly recommended. Moreover, hurdles regarding tumorigenesis, graft cell death, immune rejection and arrhythmogenesis need to be overcome in clinical practice. Here we highlight the recent progression in PSC technologies for the regeneration of injured heart. We review novel strategies that might overcome current obstacles in heart regenerative medicine, aiming at improving cell survival and functional integration after cell transplantation." @default.
- W2582809270 created "2017-02-03" @default.
- W2582809270 creator A5066895852 @default.
- W2582809270 creator A5080157924 @default.
- W2582809270 date "2017-02-01" @default.
- W2582809270 modified "2023-10-16" @default.
- W2582809270 title "Stem Cell Technology in Cardiac Regeneration: A Pluripotent Stem Cell Promise" @default.
- W2582809270 cites W1496905404 @default.
- W2582809270 cites W1762620449 @default.
- W2582809270 cites W1860321656 @default.
- W2582809270 cites W1907511822 @default.
- W2582809270 cites W1967367827 @default.
- W2582809270 cites W1970288681 @default.
- W2582809270 cites W1977025496 @default.
- W2582809270 cites W1978593765 @default.
- W2582809270 cites W1980724266 @default.
- W2582809270 cites W1985223008 @default.
- W2582809270 cites W1987774343 @default.
- W2582809270 cites W1988397986 @default.
- W2582809270 cites W1988451304 @default.
- W2582809270 cites W1991865594 @default.
- W2582809270 cites W1991882394 @default.
- W2582809270 cites W1999197334 @default.
- W2582809270 cites W2000949542 @default.
- W2582809270 cites W2003996125 @default.
- W2582809270 cites W2009184449 @default.
- W2582809270 cites W2011300713 @default.
- W2582809270 cites W2013384776 @default.
- W2582809270 cites W2014286916 @default.
- W2582809270 cites W2018771531 @default.
- W2582809270 cites W2019229253 @default.
- W2582809270 cites W2021110745 @default.
- W2582809270 cites W2022336190 @default.
- W2582809270 cites W2027941009 @default.
- W2582809270 cites W2033562173 @default.
- W2582809270 cites W2033765226 @default.
- W2582809270 cites W2034862301 @default.
- W2582809270 cites W2036683006 @default.
- W2582809270 cites W2038887939 @default.
- W2582809270 cites W2041302454 @default.
- W2582809270 cites W2045626197 @default.
- W2582809270 cites W2045911549 @default.
- W2582809270 cites W2046013132 @default.
- W2582809270 cites W2048410503 @default.
- W2582809270 cites W2050013407 @default.
- W2582809270 cites W2050160133 @default.
- W2582809270 cites W2051493710 @default.
- W2582809270 cites W2054604628 @default.
- W2582809270 cites W2054914505 @default.
- W2582809270 cites W2054934551 @default.
- W2582809270 cites W2055313665 @default.
- W2582809270 cites W2059223857 @default.
- W2582809270 cites W2059328985 @default.
- W2582809270 cites W2061778565 @default.
- W2582809270 cites W2062215588 @default.
- W2582809270 cites W2065528132 @default.
- W2582809270 cites W2065717748 @default.
- W2582809270 cites W2065788477 @default.
- W2582809270 cites W2067591094 @default.
- W2582809270 cites W2069019884 @default.
- W2582809270 cites W2070261693 @default.
- W2582809270 cites W2075469935 @default.
- W2582809270 cites W2077806591 @default.
- W2582809270 cites W2078215784 @default.
- W2582809270 cites W2083462941 @default.
- W2582809270 cites W2086294280 @default.
- W2582809270 cites W2086876030 @default.
- W2582809270 cites W2086943348 @default.
- W2582809270 cites W2095626826 @default.
- W2582809270 cites W2096227522 @default.
- W2582809270 cites W2096237299 @default.
- W2582809270 cites W2096493223 @default.
- W2582809270 cites W2097077362 @default.
- W2582809270 cites W2098266872 @default.
- W2582809270 cites W2099111992 @default.
- W2582809270 cites W2104229067 @default.
- W2582809270 cites W2105844388 @default.
- W2582809270 cites W2106764538 @default.
- W2582809270 cites W2111554117 @default.
- W2582809270 cites W2112214249 @default.
- W2582809270 cites W2112792041 @default.
- W2582809270 cites W2119376007 @default.
- W2582809270 cites W2122099309 @default.
- W2582809270 cites W2124256118 @default.
- W2582809270 cites W2124849526 @default.
- W2582809270 cites W2125086964 @default.
- W2582809270 cites W2125635123 @default.
- W2582809270 cites W2125987139 @default.
- W2582809270 cites W2126147950 @default.
- W2582809270 cites W2128085444 @default.
- W2582809270 cites W2132735690 @default.
- W2582809270 cites W2133127571 @default.
- W2582809270 cites W2133711544 @default.
- W2582809270 cites W2134607740 @default.
- W2582809270 cites W2138732093 @default.
- W2582809270 cites W2138977668 @default.
- W2582809270 cites W2142046859 @default.
- W2582809270 cites W2143815163 @default.