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- W2582812828 endingPage "1802" @default.
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- W2582812828 abstract "An efficient conjugatable and bioreduction cleavable linker was designed and synthesized for the 5′-terminal ends of oligonucleotides. A phosphoramidite reagent bearing this linker was successfully applied to solid phase synthesis and incorporated at the 5′-terminal ends of oligonucleotides. The controlled pore glass (CPG)-supported oligonucleotides were subsequently conjugated to a diverse range of functional molecules using a CuAAC reaction. The synthesized oligonucleotide conjugates were then cleaved using a nitroreductase/NADH bioreduction system to release the naked oligonucleotides." @default.
- W2582812828 created "2017-02-03" @default.
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- W2582812828 date "2017-01-23" @default.
- W2582812828 modified "2023-10-18" @default.
- W2582812828 title "Conjugatable and Bioreduction Cleavable Linker for the 5′-Functionalization of Oligonucleotides" @default.
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- W2582812828 doi "https://doi.org/10.1021/acs.joc.6b02527" @default.
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