FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2582904221> ?p ?o ?g. }

• W2582904221 endingPage "332" @default.
• W2582904221 startingPage "322" @default.
• W2582904221 abstract "Naegleria fowleri (N. fowleri) causes primary amoebic meningoencephalitis, a rapidly fatal disease of the central nervous system. N. fowleri can exist in cyst, flagellate or amoebic forms, depending on environmental conditions. The amoebic form can invade the brain following introduction into the nasal passages. When applied intranasally to a mouse model, cultured N. fowleri amoebae exhibit low virulence. However, upon serial passage in mouse brain, the amoebae acquire a highly virulent state. In the present study, a proteomics approach was applied to the identification of N. fowleri amoeba proteins whose expression was associated with the highly virulent state in mice. Mice were inoculated intranasally with axenically cultured amoebae or with mouse-passaged amoebae. Examination by light and electron microscopy revealed no morphological differences. However, mouse-passaged amoebae were more virulent in mice as indicated by exhibiting a two log10 titre decrease in median infective dose 50 (ID50). Scatter plot analysis of amoebic lysates revealed a subset of proteins, the expression of which was associated with highly virulent amoebae. MS-MS indicated that this subset contained proteins that shared homology with those linked to cytoskeletal rearrangement and the invasion process. Invasion assays were performed in the presence of a select inhibitor to expand on the findings. The collective results suggest that N. fowleri gene products linked to cytoskeletal rearrangement and invasion may be candidate targets in the management of primary amoebic meningoencephalitis." @default.
• W2582904221 created "2017-02-03" @default.
• W2582904221 creator A5032274242 @default.
• W2582904221 creator A5061096179 @default.
• W2582904221 creator A5070636810 @default.
• W2582904221 creator A5075180178 @default.
• W2582904221 creator A5089476680 @default.
• W2582904221 date "2017-03-01" @default.
• W2582904221 modified "2023-09-28" @default.
• W2582904221 title "Identification of Naegleria fowleri proteins linked to primary amoebic meningoencephalitis" @default.
• W2582904221 cites W1483934283 @default.
• W2582904221 cites W1546673303 @default.
• W2582904221 cites W1879900969 @default.
• W2582904221 cites W1922875257 @default.
• W2582904221 cites W1975287400 @default.
• W2582904221 cites W1996185392 @default.
• W2582904221 cites W2024368917 @default.
• W2582904221 cites W2031935272 @default.
• W2582904221 cites W2033582873 @default.
• W2582904221 cites W2056791463 @default.
• W2582904221 cites W2060732178 @default.
• W2582904221 cites W2070623632 @default.
• W2582904221 cites W2070657240 @default.
• W2582904221 cites W2076633416 @default.
• W2582904221 cites W2077952267 @default.
• W2582904221 cites W2108432748 @default.
• W2582904221 cites W2122605561 @default.
• W2582904221 cites W2137203430 @default.
• W2582904221 cites W2137245547 @default.
• W2582904221 cites W2137973760 @default.
• W2582904221 cites W2139373075 @default.
• W2582904221 cites W2167330005 @default.
• W2582904221 cites W2169094718 @default.
• W2582904221 cites W2171818688 @default.
• W2582904221 cites W2172233181 @default.
• W2582904221 cites W2181019606 @default.
• W2582904221 cites W2255091781 @default.
• W2582904221 cites W2316716156 @default.
• W2582904221 cites W2330338873 @default.
• W2582904221 cites W2336732132 @default.
• W2582904221 cites W3213563054 @default.
• W2582904221 cites W4241514801 @default.
• W2582904221 cites W4242013036 @default.
• W2582904221 doi "https://doi.org/10.1099/mic.0.000428" @default.
• W2582904221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28086072" @default.
• W2582904221 hasPublicationYear "2017" @default.
• W2582904221 type Work @default.
• W2582904221 sameAs 2582904221 @default.
• W2582904221 citedByCount "13" @default.
• W2582904221 countsByYear W25829042212018 @default.
• W2582904221 countsByYear W25829042212019 @default.
• W2582904221 countsByYear W25829042212020 @default.
• W2582904221 countsByYear W25829042212021 @default.
• W2582904221 countsByYear W25829042212023 @default.
• W2582904221 crossrefType "journal-article" @default.
• W2582904221 hasAuthorship W2582904221A5032274242 @default.
• W2582904221 hasAuthorship W2582904221A5061096179 @default.
• W2582904221 hasAuthorship W2582904221A5070636810 @default.
• W2582904221 hasAuthorship W2582904221A5075180178 @default.
• W2582904221 hasAuthorship W2582904221A5089476680 @default.
• W2582904221 hasBestOaLocation W25829042211 @default.
• W2582904221 hasConcept C104317684 @default.
• W2582904221 hasConcept C159047783 @default.
• W2582904221 hasConcept C2776172558 @default.
• W2582904221 hasConcept C2776505691 @default.
• W2582904221 hasConcept C2778566189 @default.
• W2582904221 hasConcept C2778621254 @default.
• W2582904221 hasConcept C2778868110 @default.
• W2582904221 hasConcept C2781155112 @default.
• W2582904221 hasConcept C54355233 @default.
• W2582904221 hasConcept C60987743 @default.
• W2582904221 hasConcept C86803240 @default.
• W2582904221 hasConcept C89423630 @default.
• W2582904221 hasConceptScore W2582904221C104317684 @default.
• W2582904221 hasConceptScore W2582904221C159047783 @default.
• W2582904221 hasConceptScore W2582904221C2776172558 @default.
• W2582904221 hasConceptScore W2582904221C2776505691 @default.
• W2582904221 hasConceptScore W2582904221C2778566189 @default.
• W2582904221 hasConceptScore W2582904221C2778621254 @default.
• W2582904221 hasConceptScore W2582904221C2778868110 @default.
• W2582904221 hasConceptScore W2582904221C2781155112 @default.
• W2582904221 hasConceptScore W2582904221C54355233 @default.
• W2582904221 hasConceptScore W2582904221C60987743 @default.
• W2582904221 hasConceptScore W2582904221C86803240 @default.
• W2582904221 hasConceptScore W2582904221C89423630 @default.
• W2582904221 hasIssue "3" @default.
• W2582904221 hasLocation W25829042211 @default.
• W2582904221 hasLocation W25829042212 @default.
• W2582904221 hasLocation W25829042213 @default.
• W2582904221 hasOpenAccess W2582904221 @default.
• W2582904221 hasPrimaryLocation W25829042211 @default.
• W2582904221 hasRelatedWork W1815704246 @default.
• W2582904221 hasRelatedWork W2049965952 @default.
• W2582904221 hasRelatedWork W2236991616 @default.
• W2582904221 hasRelatedWork W2271901944 @default.
• W2582904221 hasRelatedWork W2409089155 @default.
• W2582904221 hasRelatedWork W2415801675 @default.
• W2582904221 hasRelatedWork W2437795448 @default.

• next