Matches in SemOpenAlex for { <https://semopenalex.org/work/W2583014715> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2583014715 endingPage "686" @default.
- W2583014715 startingPage "683" @default.
- W2583014715 abstract "This study was carried out to search for mutations in the gene encoding for Non- Structural Protein 5A, specifically in the interferon sensitivity determining region of hepatitis C virus (HCV) genotype 3a, isolated from serum samples of patients not responding to treatment with oral Ribavirin and Interferon alpha injections.This descriptive case series was conducted on HCV patients reporting in the attached teaching hospitals of Peshawar Medical College selected by consecutive sampling technique from 1st July to 31st December 2012. Amino acid sequencing was performed at the Centre of Applied Molecular Biology Lahore. Patients showing no clinical response after 6 months of combination therapy with Injection Interferon alpha + Ribavirin and still having positive polymerase chain reaction (Declared Non-Responders) were included in this study.Amino acid sequencing was performed on HCV isolates from twenty non-responder and five responder patients. All these sequences were compared with Newzealand1 (NZL1) sequence from the gene bank for mutations; 0-7 mutations were observed in responders as compared to 10-27 mutations in non-responder patients (p value <0.005).We were able to determine that there is a positive correlation between the number of mutations in NS5A ISDR and non-response to combination therapy. Synonymous mutations >10 and non-synonymous mutations >7 in this region suggest poor response to treatment." @default.
- W2583014715 created "2017-02-03" @default.
- W2583014715 creator A5000815527 @default.
- W2583014715 creator A5065705000 @default.
- W2583014715 creator A5073197249 @default.
- W2583014715 creator A5076729140 @default.
- W2583014715 creator A5089849474 @default.
- W2583014715 date "2017-06-07" @default.
- W2583014715 modified "2023-09-24" @default.
- W2583014715 title "Identification Of Mutation Sites In Hepatitis C Virus Genotype 3a In Non-Responders To Combination Therapy With Interferon- Αlfa And Ribavirin In Residents Of Khyber Pakhtunkhwa Province Pakistan." @default.
- W2583014715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28586597" @default.
- W2583014715 hasPublicationYear "2017" @default.
- W2583014715 type Work @default.
- W2583014715 sameAs 2583014715 @default.
- W2583014715 citedByCount "0" @default.
- W2583014715 crossrefType "journal-article" @default.
- W2583014715 hasAuthorship W2583014715A5000815527 @default.
- W2583014715 hasAuthorship W2583014715A5065705000 @default.
- W2583014715 hasAuthorship W2583014715A5073197249 @default.
- W2583014715 hasAuthorship W2583014715A5076729140 @default.
- W2583014715 hasAuthorship W2583014715A5089849474 @default.
- W2583014715 hasConcept C104317684 @default.
- W2583014715 hasConcept C126322002 @default.
- W2583014715 hasConcept C135763542 @default.
- W2583014715 hasConcept C159047783 @default.
- W2583014715 hasConcept C2522874641 @default.
- W2583014715 hasConcept C2776178377 @default.
- W2583014715 hasConcept C2776408679 @default.
- W2583014715 hasConcept C2776999253 @default.
- W2583014715 hasConcept C2777103181 @default.
- W2583014715 hasConcept C2780040827 @default.
- W2583014715 hasConcept C2781463415 @default.
- W2583014715 hasConcept C2909179924 @default.
- W2583014715 hasConcept C2994225774 @default.
- W2583014715 hasConcept C501734568 @default.
- W2583014715 hasConcept C54355233 @default.
- W2583014715 hasConcept C71924100 @default.
- W2583014715 hasConcept C86803240 @default.
- W2583014715 hasConcept C90924648 @default.
- W2583014715 hasConceptScore W2583014715C104317684 @default.
- W2583014715 hasConceptScore W2583014715C126322002 @default.
- W2583014715 hasConceptScore W2583014715C135763542 @default.
- W2583014715 hasConceptScore W2583014715C159047783 @default.
- W2583014715 hasConceptScore W2583014715C2522874641 @default.
- W2583014715 hasConceptScore W2583014715C2776178377 @default.
- W2583014715 hasConceptScore W2583014715C2776408679 @default.
- W2583014715 hasConceptScore W2583014715C2776999253 @default.
- W2583014715 hasConceptScore W2583014715C2777103181 @default.
- W2583014715 hasConceptScore W2583014715C2780040827 @default.
- W2583014715 hasConceptScore W2583014715C2781463415 @default.
- W2583014715 hasConceptScore W2583014715C2909179924 @default.
- W2583014715 hasConceptScore W2583014715C2994225774 @default.
- W2583014715 hasConceptScore W2583014715C501734568 @default.
- W2583014715 hasConceptScore W2583014715C54355233 @default.
- W2583014715 hasConceptScore W2583014715C71924100 @default.
- W2583014715 hasConceptScore W2583014715C86803240 @default.
- W2583014715 hasConceptScore W2583014715C90924648 @default.
- W2583014715 hasIssue "4" @default.
- W2583014715 hasLocation W25830147151 @default.
- W2583014715 hasOpenAccess W2583014715 @default.
- W2583014715 hasPrimaryLocation W25830147151 @default.
- W2583014715 hasRelatedWork W1915650547 @default.
- W2583014715 hasRelatedWork W2011283117 @default.
- W2583014715 hasRelatedWork W2025611101 @default.
- W2583014715 hasRelatedWork W2035777056 @default.
- W2583014715 hasRelatedWork W207112961 @default.
- W2583014715 hasRelatedWork W2079005798 @default.
- W2583014715 hasRelatedWork W2097932782 @default.
- W2583014715 hasRelatedWork W2165188981 @default.
- W2583014715 hasRelatedWork W2196041441 @default.
- W2583014715 hasRelatedWork W2272061742 @default.
- W2583014715 hasRelatedWork W2350316900 @default.
- W2583014715 hasRelatedWork W2387492680 @default.
- W2583014715 hasRelatedWork W2400679472 @default.
- W2583014715 hasRelatedWork W2413339760 @default.
- W2583014715 hasRelatedWork W2522226204 @default.
- W2583014715 hasRelatedWork W2775610553 @default.
- W2583014715 hasRelatedWork W2796948424 @default.
- W2583014715 hasRelatedWork W2954506899 @default.
- W2583014715 hasRelatedWork W3029988230 @default.
- W2583014715 hasRelatedWork W3181254246 @default.
- W2583014715 hasVolume "28" @default.
- W2583014715 isParatext "false" @default.
- W2583014715 isRetracted "false" @default.
- W2583014715 magId "2583014715" @default.
- W2583014715 workType "article" @default.