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• W2583018095 endingPage "33" @default.
• W2583018095 startingPage "24" @default.
• W2583018095 abstract "Metformin, a widely prescribed drug for treating type II diabetes, is one of the most extensively recognized metabolic modulators which has shown an important anti-cancer property. However, fairly amount of clinical trials on its single administration have not demonstrated a convincing efficiency yet. Thus, recent studies tend to combine metformin with clinical commonly used chemotherapeutic drugs to decrease their toxicity and attenuate their tumor resistance. These strategies have displayed promising clinical benefits. Interestingly, metformin experiences a diversity of molecular mechanisms when it combines different chemotherapeutic drugs. For example, AMPK/mTOR signaling pathway activation plays a major role when it combines with hormone modulating drugs. In contrast, suppression of HIF-1, p-gp and MRP1 protein expression is its main mechanism when metformin combines with anti-metabolites. Furthermore, when combining of metformin with antibiotics, inhibition of oxidative stress and inflammatory signaling pathway becomes a novel pharmaceutical mechanism for its cardio-protective effect. Induction of apoptotic mitochondria and nucleus could be the major player for the synergistic effect of its combination with cisplatin. In contrast, down-regulation of lipoprotein or cholesterol synthesis might be the undefined molecular base when metformin combines with taxane. Thus, deep exploration of molecular mechanisms of metformin with these different drugs is critical to understand its synergistic effect and help for personalized administration. In this mini-review, detailed molecular mechanisms of these combinations are discussed and summarized. This work will promote better understanding of molecular mechanisms of metformin and provide precise targets to identify specific patient groups to achieve satisfactory treatment efficacy." @default.
• W2583018095 created "2017-02-03" @default.
• W2583018095 creator A5008953620 @default.
• W2583018095 creator A5014553834 @default.
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• W2583018095 creator A5025994163 @default.
• W2583018095 creator A5034447562 @default.
• W2583018095 creator A5049709100 @default.
• W2583018095 creator A5058860533 @default.
• W2583018095 creator A5069144644 @default.
• W2583018095 creator A5075883718 @default.
• W2583018095 date "2017-03-01" @default.
• W2583018095 modified "2023-10-02" @default.
• W2583018095 title "Combination of metformin with chemotherapeutic drugs via different molecular mechanisms" @default.
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