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- W2583038916 abstract "Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic phenotype and is involved in virtually all aspects of cellular function. It integrates not only nutrient and energy-sensing pathways but also actin cytoskeleton organization, in response to environmental cues including growth factors and cellular energy levels. These events are pivotal for spermatogenesis and determine the reproductive potential of males. Yet, the molecular mechanisms by which mTOR signaling acts in male reproductive system remain a matter of debate. Here, we review the current knowledge on physiological and molecular events mediated by mTOR in testis and testicular cells. In recent years, mTOR inhibition has been explored as a prime strategy to develop novel therapeutic approaches to treat cancer, cardiovascular disease, autoimmunity, and metabolic disorders. However, the physiological consequences of mTOR dysregulation and inhibition to male reproductive potential are still not fully understood. Compelling evidence suggests that mTOR is an arising regulator of male fertility and better understanding of this atypical protein kinase coordinated action in testis will provide insightful information concerning its biological significance in other tissues/organs. We also discuss why a new generation of mTOR inhibitors aiming to be used in clinical practice may also need to include an integrative view on the effects in male reproductive system." @default.
- W2583038916 created "2017-02-03" @default.
- W2583038916 creator A5021022567 @default.
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- W2583038916 creator A5027023125 @default.
- W2583038916 creator A5072413923 @default.
- W2583038916 creator A5073431252 @default.
- W2583038916 date "2017-01-26" @default.
- W2583038916 modified "2023-10-17" @default.
- W2583038916 title "Mammalian target of rapamycin (mTOR): a central regulator of male fertility?" @default.
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